PDB: 13413 件ウェブページステータス検索Chemie searchBIRD

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6IRW	Crystal structure of the human cap-specific adenosine methyltransferase bound to SAH 分子名称: Phosphorylated CTD-interacting factor 1, S-ADENOSYL-L-HOMOCYSTEINE 著者 Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. 登録日 2018-11-14 公開日 2018-12-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. Science, 363, 2019
3ER9	Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase complex with UU and 3'-deoxy ATP 分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-R(UP*U)-3', CALCIUM ION, ... 著者 Li, C, Li, H, Zhou, S, Poulos, T.L, Gershon, P.D. 登録日 2008-10-01 公開日 2009-06-16 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase Structure, 17, 2009
3MF5	Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor 分子名称: 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid, GLYCEROL, RNA-directed RNA polymerase 著者 Harris, S.F, Tavares, G, Ghate, M. 登録日 2010-04-01 公開日 2010-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
7UMR	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-1 (trans-form) 分子名称: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-04-07 公開日 2022-10-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
2O1P	Structure of yeast Poly(A) Polymerase in a somewhat closed state 分子名称: Poly(A) polymerase 著者 Bohm, A, Balbo, P, Toth, J. 登録日 2006-11-29 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase. J.Mol.Biol., 366, 2007
6P1S	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated AMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
7EGQ	Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading 分子名称: Helicase, MAGNESIUM ION, Non-structural protein 10, ... 著者 Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. 登録日 2021-03-25 公開日 2021-07-21 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184, 2021
6P1U	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated CMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
7ZPY	Influenza polymerase A C-terminal domain of PA subunit with optimized small peptide inhibitor 分子名称: METHOXY-ETHOXYL, Peptide inhibitor (ASP-TYR-ASN-PRO-TYR-LEU-LEU-TYR-LEU-LYS), Polymerase acidic protein 著者 Radilova, K, Brynda, J. 登録日 2022-04-29 公開日 2022-10-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction. Antiviral Res., 208, 2022
8JLA	Cryo-EM structure of the human nucleosome lacking N-terminal region of H2A, H2B, H3, and H4 分子名称: DNA (193-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. 登録日 2023-06-02 公開日 2023-10-04 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
6C6S	CryoEM structure of E.coli RNA polymerase elongation complex bound with RfaH 分子名称: DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Kang, J.Y, Artsimovitch, I, Landick, R, Darst, S.A. 登録日 2018-01-19 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators. Cell, 173, 2018
6C6U	CryoEM structure of E.coli RNA polymerase elongation complex bound with NusG 分子名称: DNA (29-MER), DNA-DIRECTED RNA POLYMERASE BETA', DNA-directed RNA polymerase subunit alpha, ... 著者 Kang, J.Y, Artsimovitch, I, Landick, R, Darst, S.A. 登録日 2018-01-19 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators. Cell, 173, 2018
6C6T	CryoEM structure of E.coli RNA polymerase elongation complex bound with RfaH 分子名称: DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Kang, J.Y, Artsimovitch, I, Landick, R, Darst, S.A. 登録日 2018-01-19 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators. Cell, 173, 2018
4KBM	Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex 分子名称: DNA-directed RNA polymerase subunit beta, RNA polymerase-binding transcription factor CarD 著者 Gulten, G, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2013-04-23 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1146 Å) 主引用文献 Structure of the Mtb CarD/RNAP beta-Lobes Complex Reveals the Molecular Basis of Interaction and Presents a Distinct DNA-Binding Domain for Mtb CarD. Structure, 21, 2013
5ZIT	Crystal structure of human Enterovirus D68 RdRp in complex with NADPH 分子名称: DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RdRp 著者 Wang, M.L, Li, L, Chen, Y.P, Jiang, H, Zhang, Y, Su, D. 登録日 2018-03-17 公開日 2019-04-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.196 Å) 主引用文献 Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel. J.Struct.Biol., 2020
4NZ0	The EMCV 3Dpol structure at 2.8A resolution 分子名称: CHLORIDE ION, GLYCEROL, Genome polyprotein 著者 Vives-adrian, L, Ferrer-orta, C, Verdaguer, N. 登録日 2013-12-11 公開日 2014-03-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site J.Virol., 88, 2014
4NYZ	The EMCV 3Dpol structure with altered motif A conformation at 2.15A resolution 分子名称: GLUTAMINE, GLYCEROL, Genome polyprotein, ... 著者 Vives-adrian, L, Lujan, C, Ferrer-orta, C, Verdaguer, N. 登録日 2013-12-11 公開日 2014-03-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site J.Virol., 88, 2014
7EIZ	Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading 分子名称: Helicase, MAGNESIUM ION, Non-structural protein 10, ... 著者 Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. 登録日 2021-04-01 公開日 2021-09-22 最終更新日 2023-07-26 実験手法 ELECTRON MICROSCOPY 主引用文献 Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading Cell, 184, 2021
2BRK	Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1) 分子名称: 3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S, Volpari, C, Carfi, A. 登録日 2005-05-06 公開日 2005-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280, 2005
2BRL	Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 2) 分子名称: 3-CYCLOHEXYL-1-(2-{METHYL[(1-METHYLPIPERIDIN-3-YL)METHYL]AMINO}-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S, Volpari, C, Carfi, A. 登録日 2005-05-06 公開日 2005-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280, 2005
6ASG	Crystal structure of Thermus thermophilus RNA polymerase core enzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Liu, Y, Lin, W, Ying, R, Ebright, R.H. 登録日 2017-08-24 公開日 2018-04-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
7X6S	lymphocytic choriomeningitis virus RNA-dependent RNA polymerase (LCMV-L protein) 分子名称: MANGANESE (II) ION, RNA-directed RNA polymerase L 著者 Liu, L, Lou, Z. 登録日 2022-03-08 公開日 2023-09-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
4YD2	Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate 分子名称: CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... 著者 Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. 登録日 2015-02-20 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.471 Å) 主引用文献 Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
4YCX	Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate 分子名称: DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), DNA (5'-D(P*GP*CP*CP*G)-3'), ... 著者 Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. 登録日 2015-02-20 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
4LQ9	Crystal structure of human norovirus RNA-dependent RNA-polymerase in complex with NAF2 分子名称: MAGNESIUM ION, RNA-dependent RNA-polymerase, naphthalene-1,5-disulfonic acid 著者 Milani, M, Tarantino, D, Mastrangelo, E, Croci, R. 登録日 2013-07-17 公開日 2014-02-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase. Antiviral Res., 102, 2014

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