PDB: 217686 件ウェブページステータス検索Chemie searchBIRD

---

8CK4	STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH (4S)-1-(3,5-difluorophenyl)-5,5-difluoro-3-methanesulfonyl-4,5,6,7-tetrahydro-2-benzothiophen-4-ol 分子名称: (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-6,7-dihydro-4~{H}-2-benzothiophen-4-ol, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 著者 Musil, D. 登録日 2023-02-14 公開日 2023-07-19 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors. J.Med.Chem., 66, 2023
6VIP	TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008 分子名称: TP53-binding protein 1, UNKNOWN ATOM OR ION, {4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone 著者 The, J, Hong, Z, Dong, A, Headey, S, Gunzburg, M, Doak, B, James, L.I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2020-01-13 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008 to be published
7QNU	SMYD3 in complex with fragment FL08619 分子名称: BENZOYL-FORMIC ACID, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2021-12-22 公開日 2023-04-05 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening Rsc Med Chem, 2024
6BGE	HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH 1G2 COMPOUND 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[(pyridin-2-yl)oxy]benzoic acid, GLYCEROL, ... 著者 Arya, T, Casu, B, Baron, C. 登録日 2017-10-27 公開日 2018-10-31 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 CagAlpha in complex with hexamer inhibitor To Be Published
6SJ5	Crystal structure of the uL14-RsfS complex from Staphylococcus aureus 分子名称: 50S ribosomal protein L14, ACETIC ACID, PHOSPHATE ION, ... 著者 Fatkhullin, B, Gabdulkhakov, A, Yusupova, G, Yusupov, M. 登録日 2019-08-12 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.26686549 Å) 主引用文献 Mechanism of ribosome shutdown by RsfS in Staphylococcus aureus revealed by integrative structural biology approach. Nat Commun, 11, 2020
7QNR	SMYD3 in complex with fragment FL01791 分子名称: 3-propan-2-yl-1,2,4-thiadiazol-5-amine, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2021-12-22 公開日 2023-04-05 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening Rsc Med Chem, 2024
8AN4	MenT1 toxin (rv0078a) from Mycobacterium tuberculosis H37Rv 分子名称: Bacterial toxin 著者 Xu, X, Usher, B, Gutierrez, C, Barriot, R, Arrowsmith, T.J, Han, X, Redder, P, Neyrolles, O, Blower, T.R, Genevaux, P. 登録日 2022-08-04 公開日 2023-08-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding. Nat Commun, 14, 2023
8AN5	MenAT1 toxin-antitoxin complex (rv0078a-rv0078b) from Mycobacterium tuberculosis H37Rv 分子名称: Bacterial toxin, Conserved protein 著者 Xu, X, Usher, B, Gutierrez, C, Barriot, R, Arrowsmith, T.J, Han, X, Redder, P, Neyrolles, O, Blower, T.R, Genevaux, P. 登録日 2022-08-04 公開日 2023-08-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding. Nat Commun, 14, 2023
4L99	Structure of the RBP from lactococcal phage 1358 in complex with glycerol 分子名称: GLYCEROL, Receptor Binding Protein, ZINC ION 著者 Farenc, C, Spinelli, S, Bebeacua, C, Tremblay, D, Orlov, I, Blangy, S, Klaholz, B.P, Moineau, S, Cambillau, C. 登録日 2013-06-18 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A Virulent Siphophage CyoEM Structure and Host Recognition and Infection Mechanism To be Published
8ADX	Structure of the Reconstructed Ancestor of Phenolic Acid Decarboxylase AncPAD55 分子名称: Phenolic acid decarboxylase N55, SULFATE ION 著者 Schruefer, A, Mokos, D, Gruber, K, Daniel, B. 登録日 2022-07-12 公開日 2023-08-02 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Reconstructed ancestral sequences of bacterial phenolic acid decarboxylase show increased thermostability To Be Published
8CMB	Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Spike peptide S486-505 分子名称: 1,2-ETHANEDIOL, 2-AMINO-ETHANETHIOL, HLA class II histocompatibility antigen, ... 著者 MacLachlan, B.J, Mason, G.H, Godkin, A.J, Rizkallah, P.J. 登録日 2023-02-19 公開日 2023-07-26 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity. Cell Rep, 42, 2023
7LT1	Structure of the cGAS-like receptor human MB21D2 分子名称: Protein MB21D2, SULFATE ION 著者 Morehouse, B.R, Slavik, K.M, Kranzusch, P.J. 登録日 2021-02-18 公開日 2021-07-21 最終更新日 2021-09-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature, 597, 2021
8SXZ	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-05-24 公開日 2024-05-01 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 59, 2024
8CMH	Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Omicron (BA.1) Spike peptide S486-505 分子名称: 1,2-ETHANEDIOL, 2-AMINO-ETHANETHIOL, HLA class II histocompatibility antigen, ... 著者 MacLachlan, B.J, Mason, G.H, Sourfield, D.O, Godkin, A.J, Rizkallah, P.J. 登録日 2023-02-19 公開日 2023-07-26 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity. Cell Rep, 42, 2023
8T0R	Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state (full helix) 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-06-01 公開日 2024-05-01 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.97 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 59, 2024
4L97	Structure of the RBP of lactococcal phage 1358 in complex with glucose-1-phosphate 分子名称: 1-O-phosphono-alpha-D-glucopyranose, Receptor Binding Protein 著者 Farenc, C, Spinelli, S, Bebeacua, C, Tremblay, D, Orlov, I, Blangy, S, Klaholz, B.P, Moineau, S, Cambillau, C. 登録日 2013-06-18 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 A Virulent Siphophage CyoEM Structure and Host Recognition and Infection Mechanism To be Published
5YCR	X-Ray Structure of Enoyl-Acyl Carrier Protein Reductase from Bacillus Anthracis with NAD+ 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION 著者 Kim, H.T. 登録日 2017-09-08 公開日 2018-02-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structural insights into the dimer-tetramer transition of FabI from Bacillus anthracis Biochem. Biophys. Res. Commun., 493, 2017
8T0K	Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-06-01 公開日 2024-05-01 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 59, 2024
8SZ8	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state (full helix) 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-05-27 公開日 2024-05-01 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 59, 2024
5UCZ	Class II fructose-1,6-bisphosphate aldolase E149A variant of Helicobacter pylori with DHAP 分子名称: 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, SODIUM ION, ... 著者 Jacques, B, Sygusch, J. 登録日 2016-12-23 公開日 2018-04-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. J. Biol. Chem., 293, 2018
5M0C	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the Fasudil-fragment isoquinoline-5-sulfonamide 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-10-04 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.734 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To be Published
5M0L	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated Fasudil-derived fragment N-methylisoquinoline-5-sulfonamide (Ligand 02) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-10-05 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.465 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published
6BQ5	Crystal structure of Medicago truncatula Thermospermine Synthase (MtTSPS) in complex with 5'-methylthioadenosine 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ... 著者 Sekula, B, Dauter, Z. 登録日 2017-11-27 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of thermospermine synthase fromMedicago truncatulaand substrate discriminatory features of plant aminopropyltransferases. Biochem. J., 475, 2018
6BP0	Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor 分子名称: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Counago, R.M, dos Reis, C.V, de Souza, G.P, Azevedo, A, Guimaraes, C, Mascarello, A, Gama, F, Ferreira, M, Massirer, K.B, Arruda, P, Edwards, A.M, Elkins, J, Structural Genomics Consortium (SGC) 登録日 2017-11-21 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor To Be Published
5C0Y	Crystal structure of the Rrp6 catalytic domain bound to poly(U) RNA 分子名称: Exosome complex exonuclease RRP6, MAGNESIUM ION, poly U RNA 著者 Schuch, B, Conti, E. 登録日 2015-06-12 公開日 2015-08-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 RNA degradation paths in a 12-subunit nuclear exosome complex. Nature, 524, 2015

<694695696697698699700701702703704705706707708709>