6BP0
Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor
Summary for 6BP0
Entry DOI | 10.2210/pdb6bp0/pdb |
Descriptor | Serine/threonine-protein kinase VRK1, CHLORIDE ION, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one, ... (7 entities in total) |
Functional Keywords | transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 166105.77 |
Authors | Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.,Structural Genomics Consortium (SGC) (deposition date: 2017-11-21, release date: 2017-12-06, Last modification date: 2023-10-04) |
Primary citation | Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.,Structural Genomics Consortium (SGC) Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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