6K1A
 
 | | Crystal structure of EXD2 exonuclease domain soaked in Mn and Mg | | 分子名称: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION, MANGANESE (II) ION | | 著者 | Park, J, Lee, C. | | 登録日 | 2019-05-10 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
|
|
6I0B
 | | Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor. | | 分子名称: | (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Brazzolotto, X, Nachon, F. | | 登録日 | 2018-10-25 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.384 Å) | | 主引用文献 | Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Eur.J.Med.Chem., 168, 2019
|
|
6K1B
 | |
6K19
 | | Crystal structure of EXD2 exonuclease domain soaked in Mg | | 分子名称: | Exonuclease 3'-5' domain-containing protein 2, MAGNESIUM ION | | 著者 | Park, J, Lee, C. | | 登録日 | 2019-05-10 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | | 主引用文献 | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
|
|
6K17
 | | Crystal structure of EXD2 exonuclease domain | | 分子名称: | Exonuclease 3'-5' domain-containing protein 2, SODIUM ION | | 著者 | Park, J, Lee, C. | | 登録日 | 2019-05-10 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
|
|
6K1E
 | |
2OLE
 | | Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Cyclic Hydrazine Derivatives | | 分子名称: | (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE, Dipeptidyl peptidase 4 | | 著者 | Kim, S.S, Ahn, J.H, Lee, J.O. | | 登録日 | 2007-01-19 | | 公開日 | 2008-01-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors
Bioorg.Med.Chem.Lett., 17, 2007
|
|
7YCJ
 | |
3EIO
 | | Crystal Structure Analysis of DPPIV Inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-({4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl}carbonyl)benzoic acid, ... | | 著者 | Ahn, J.H, Lee, J.-O. | | 登録日 | 2008-09-17 | | 公開日 | 2008-11-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
|
|
1JY2
 | | Crystal Structure of the Central Region of Bovine Fibrinogen (E5 fragment) at 1.4 Angstroms Resolution | | 分子名称: | FIBRINOGEN ALPHA CHAIN, FIBRINOGEN BETA CHAIN, FIBRINOGEN GAMMA-B CHAIN | | 著者 | Madrazo, J, Brown, J.H, Litvinovich, S, Dominguez, R, Yakovlev, S, Medved, L, Cohen, C. | | 登録日 | 2001-09-10 | | 公開日 | 2001-10-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution.
Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
1JY3
 | | Crystal Structure of the Central Region of Bovine Fibrinogen (E5 Fragment) at 1.4 Angstroms Resolution | | 分子名称: | FIBRINOGEN ALPHA CHAIN, FIBRINOGEN BETA CHAIN, FIBRINOGEN GAMMA-B CHAIN | | 著者 | Madrazo, J, Brown, J.H, Litvinovich, S, Dominguez, R, Yakovlev, S, Medved, L, Cohen, C. | | 登録日 | 2001-09-10 | | 公開日 | 2001-10-17 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution.
Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
1LGR
 | |
8UUW
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12145 | | 分子名称: | 5-[2-(dimethylamino)ethoxy]-2-methyl-N-{(1R)-1-[(3P,5M)-3-(1-methyl-1H-pyrazol-4-yl)-5-(1,3-thiazol-5-yl)phenyl]ethyl}benzamide, ACETATE ION, CHLORIDE ION, ... | | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | | 登録日 | 2023-11-02 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.
Science, 383, 2024
|
|
7VWX
 | | CryoEM structure of football-shaped GroEL:ES2 with RuBisCO | | 分子名称: | Chaperonin GroEL, Co-chaperonin GroES, Ribulose bisphosphate carboxylase | | 著者 | Kim, H, Roh, S.H. | | 登録日 | 2021-11-12 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | | 主引用文献 | Cryo-EM structures of GroEL:ES 2 with RuBisCO visualize molecular contacts of encapsulated substrates in a double-cage chaperonin.
Iscience, 25, 2022
|
|
3CMJ
 | |
7X15
 | | Crystal structure of MIGA2 LD targeting domain | | 分子名称: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, FORMIC ACID, Mitoguardin 2 | | 著者 | Kim, H, Lee, C. | | 登録日 | 2022-02-23 | | 公開日 | 2022-09-14 | | 実験手法 | X-RAY DIFFRACTION (2.852 Å) | | 主引用文献 | Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
|
|
7X14
 | | Crystal structure of phospho-FFAT motif of MIGA2 bound to VAPB | | 分子名称: | MIGA2 phospho FFAT motif, SULFATE ION, Vesicle-associated membrane protein-associated protein B | | 著者 | Kim, H, Lee, C. | | 登録日 | 2022-02-23 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.675 Å) | | 主引用文献 | Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
|
|
7YO8
 | |
4LYW
 | |
4LZR
 | | Crystal Structure of BRD4(1) bound to Colchicine | | 分子名称: | Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide | | 著者 | Wohlwend, D, Gerhardt, S, Einsle, O, Huegle, M. | | 登録日 | 2013-08-01 | | 公開日 | 2014-01-15 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
Angew.Chem.Int.Ed.Engl., 52, 2013
|
|
4LYI
 | | Crystal Structure of apo-BRD4(1) | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, IODIDE ION, ... | | 著者 | Wohlwend, D. | | 登録日 | 2013-07-31 | | 公開日 | 2014-01-15 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
Angew.Chem.Int.Ed.Engl., 52, 2013
|
|
4DK1
 | |
4DK0
 | |
3QQU
 | | Cocrystal structure of unphosphorylated igf with pyrimidine 8 | | 分子名称: | Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | | 著者 | Huang, X. | | 登録日 | 2011-02-16 | | 公開日 | 2011-04-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
|
|
3Q8W
 | | A b-aminoacyl containing thiazolidine derivative and DPPIV complex | | 分子名称: | Dipeptidyl peptidase 4, N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine | | 著者 | Lee, J.O, Song, D.H. | | 登録日 | 2011-01-07 | | 公開日 | 2011-03-16 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | | 主引用文献 | Discovery of b-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors
To be Published
|
|
