6I0B

Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor.

Summary for 6I0B

• Entry DOI: 10.2210/pdb6i0b/pdb
• Descriptor: Cholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: butyrylcholinesterase, hydrolase, multi-target inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 63294.89

Authors

Brazzolotto, X.,Nachon, F. (deposition date: 2018-10-25, release date: 2019-03-27, Last modification date: 2024-01-24)

• Primary citation: Chalupova, K.,Korabecny, J.,Bartolini, M.,Monti, B.,Lamba, D.,Caliandro, R.,Pesaresi, A.,Brazzolotto, X.,Gastellier, A.J.,Nachon, F.,Pejchal, J.,Jarosova, M.,Hepnarova, V.,Jun, D.,Hrabinova, M.,Dolezal, R.,Zdarova Karasova, J.,Mzik, M.,Kristofikova, Z.,Misik, J.,Muckova, L.,Jost, P.,Soukup, O.,Benkova, M.,Setnicka, V.,Habartova, L.,Chvojkova, M.,Kleteckova, L.,Vales, K.,Mezeiova, E.,Uliassi, E.,Valis, M.,Nepovimova, E.,Bolognesi, M.L.,Kuca, K.; Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.; Eur.J.Med.Chem., 168:491-514, 2019; PubMed: 30851693; DOI: 10.1016/j.ejmech.2019.02.021

Experimental method

X-RAY DIFFRACTION (2.384 Å)