3Q8W

A b-aminoacyl containing thiazolidine derivative and DPPIV complex

Summary for 3Q8W

• Entry DOI: 10.2210/pdb3q8w/pdb
• Descriptor: Dipeptidyl peptidase 4, N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine (2 entities in total)
• Functional Keywords: rossmann fold, hydrolase, membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P27487
• Total number of polymer chains: 2
• Total formula weight: 171267.69

Authors

Lee, J.O.,Song, D.H. (deposition date: 2011-01-07, release date: 2011-03-16, Last modification date: 2011-07-13)

• Primary citation: Park, W.S.,Kang, S.K.,Jun, M.A.,Shin, M.S.,Kim, K.Y.,Rhee, S.D.,Bae, M.A.,Kim, M.S.,Kim, K.R.,Kang, N.S.,Yoo, S.E.,Lee, J.O.,Song, D.H.,Silinski, P.,Schneider, S.E.,Ahn, J.H.,Kim, S.S.; Discovery of b-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (3.64 Å)