2OLE
Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Cyclic Hydrazine Derivatives
Summary for 2OLE
Entry DOI | 10.2210/pdb2ole/pdb |
Descriptor | Dipeptidyl peptidase 4, (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE (3 entities in total) |
Functional Keywords | dipeptidyl peptidase iv, cyclic hydrazine, diabetes, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P27487 |
Total number of polymer chains | 2 |
Total formula weight | 169764.11 |
Authors | |
Primary citation | Ahn, J.H.,Shin, M.S.,Jun, M.A.,Jung, S.H.,Kang, S.K.,Kim, K.R.,Rhee, S.D.,Kang, N.S.,Kim, S.Y.,Sohn, S.K.,Kim, S.G.,Jin, M.S.,Lee, J.O.,Cheon, H.G.,Kim, S.S. Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors Bioorg.Med.Chem.Lett., 17:2622-2628, 2007 Cited by PubMed: 17331715DOI: 10.1016/j.bmcl.2007.01.111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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