7S6C
 
 | | CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure | | 分子名称: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 4'-PHOSPHOPANTETHEINE, 6-deoxyerythronolide-B synthase EryA2, ... | | 著者 | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-11-03 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Modular polyketide synthase contains two reaction chambers that operate asynchronously.
Science, 374, 2021
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7S6D
 | | CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure | | 分子名称: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, ... | | 著者 | Bagde, S.R, Kim, C.-Y, Fromme, J.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-11-03 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Modular polyketide synthase contains two reaction chambers that operate asynchronously.
Science, 374, 2021
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1M1M
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2GP6
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2AJ9
 | | X-ray crystal structure of W42A,R161A double mutant of Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase III | | 著者 | Brown, A.K, Sridharan, S, Kremer, L, Lindenberg, S, Dover, L.G, Sacchettini, J.C, Besra, G.S. | | 登録日 | 2005-08-01 | | 公開日 | 2005-08-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Probing the Mechanism of the Mycobacterium tuberculosis beta-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: Factors Influencing Catalysis And Substrate Specificity.
J.Biol.Chem., 280, 2005
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1J3N
 | | Crystal Structure of 3-oxoacyl-(acyl-carrier protein) Synthase II from Thermus thermophilus HB8 | | 分子名称: | 3-oxoacyl-(acyl-carrier protein) synthase II, CITRIC ACID, MAGNESIUM ION | | 著者 | Bagautdinov, B, Miyano, M, Tahirov, T.H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-02-10 | | 公開日 | 2003-03-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.F, 64, 2008
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4EWP
 | | Crystal structure of FabH from Micrococcus luteus | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | | 著者 | Pereira, J.H, Goh, E.-B, Keasling, J.D, Beller, H.R, Adams, P.D. | | 登録日 | 2012-04-27 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Structure of FabH and factors affecting the distribution of branched fatty acids in Micrococcus luteus.
Acta Crystallogr.,Sect.D, 68, 2012
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3HQJ
 | | Structure-function analysis of Mycobacterium tuberculosis acyl carrier protein synthase (AcpS). | | 分子名称: | COENZYME A, Holo-[acyl-carrier-protein] synthase, MAGNESIUM ION | | 著者 | Dym, O, Albeck, S, Peleg, Y, Schwarz, A, Shakked, Z, Burstein, Y, Zimhony, O, Israel Structural Proteomics Center (ISPC) | | 登録日 | 2009-06-07 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.
J.Mol.Biol., 393, 2009
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1KP9
 | | Crystal structure of mycolic acid cyclopropane synthase CmaA1, apo-form | | 分子名称: | ACETIC ACID, CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 | | 著者 | Huang, C.-C, Smith, C.V, Jacobs Jr, W.R, Glickman, M.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2001-12-30 | | 公開日 | 2002-01-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
J.Biol.Chem., 277, 2002
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7S6B
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4JV3
 | | Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin | | 分子名称: | 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, Beta-ketoacyl synthase | | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2013-03-25 | | 公開日 | 2013-05-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
Proteins, 88, 2020
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1EBL
 | | THE 1.8 A CRYSTAL STRUCTURE AND ACTIVE SITE ARCHITECTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH) FROM ESCHERICHIA COLI | | 分子名称: | BETA-KETOACYL-ACP SYNTHASE III, COENZYME A | | 著者 | Davies, C, Heath, R.J, White, S.W, Rock, C.O. | | 登録日 | 2000-01-24 | | 公開日 | 2000-02-11 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure Fold.Des., 8, 2000
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5VBX
 | | Crystal structure of holo-[acyl-carrier-protein] synthase (AcpS) from Escherichia coli | | 分子名称: | 1,2-ETHANEDIOL, Holo-[acyl-carrier-protein] synthase, SODIUM ION | | 著者 | Marcella, A.M, Barb, A.W. | | 登録日 | 2017-03-30 | | 公開日 | 2017-11-01 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure, High Affinity, and Negative Cooperativity of the Escherichia coli Holo-(Acyl Carrier Protein):Holo-(Acyl Carrier Protein) Synthase Complex.
J. Mol. Biol., 429, 2017
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5VCB
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1IGX
 | | Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1. | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5,8,11,14,17-EICOSAPENTAENOIC ACID, ... | | 著者 | Malkowski, M.G, Thuresson, E.D, Smith, W.L, Garavito, R.M. | | 登録日 | 2001-04-18 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276, 2001
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5HM3
 | | 2.25 Angstrom Resolution Crystal Structure of Long-chain-fatty-acid-AMP Ligase FadD32 from Mycobacterium tuberculosis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine | | 分子名称: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Minasov, G, Warwrzak, Z, Kuhn, M.L, Shuvalova, L, Flores, K.J, Wilson, D.J, Grimes, K.D, Aldrich, C.C, Anderson, W.A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-01-15 | | 公開日 | 2016-08-03 | | 最終更新日 | 2016-09-07 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.
Acs Infect Dis., 2, 2016
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1IGZ
 | | Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1. | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Malkowski, M.G, Thuresson, E.D, Smith, W.L, Garavito, R.M. | | 登録日 | 2001-04-18 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
J.Biol.Chem., 276, 2001
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5ICR
 | | 2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine. | | 分子名称: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, Acyl-CoA synthase, CHLORIDE ION, ... | | 著者 | Minasov, G, Shuvalova, L, Hung, D, Fisher, S.L, Edelstein, J, Kiryukhina, O, Dubrovska, I, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-02-23 | | 公開日 | 2016-04-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | 2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.
To Be Published
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3ROW
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3S23
 | | Crystal structure of cerulenin bound Xanthomonas campestri oleA (co-crystal) Xe Derivative | | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, 3-oxoacyl-[ACP] synthase III, ... | | 著者 | Goblirsch, B.R, Wilmot, C.M. | | 登録日 | 2011-05-16 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9484 Å) | | 主引用文献 | Crystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty Acids.
Biochemistry, 51, 2012
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3S21
 | | Crystal structure of cerulenin bound Xanthomonas campestri OleA (co-crystal) | | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, 3-oxoacyl-[ACP] synthase III, ... | | 著者 | Goblirsch, B.R, Wilmot, C.M. | | 登録日 | 2011-05-16 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7001 Å) | | 主引用文献 | Crystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty Acids.
Biochemistry, 51, 2012
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3S20
 | | Crystal structure of cerulenin bound Xanthomonas campestri OleA (soak) | | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, 3-oxoacyl-[ACP] synthase III, ... | | 著者 | Goblirsch, B.R, Wilmot, C.M. | | 登録日 | 2011-05-16 | | 公開日 | 2012-05-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8796 Å) | | 主引用文献 | Crystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty Acids.
Biochemistry, 51, 2012
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3S1Z
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5CEJ
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5CDY
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