PDB: 386 件ウェブページステータス検索Chemie searchBIRD

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7R1V	Crystal structure of E.coli BamA beta-barrel in complex with dynobactin A 分子名称: Dynobactin A, Outer membrane protein assembly factor BamA 著者 Jakob, R.P, Hiller, S, Maier, T. 登録日 2022-02-03 公開日 2022-09-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
7R1W	E. coli BAM complex (BamABCDE) bound to dynobactin A 分子名称: Dynobactin A, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... 著者 Jakob, R.P, Hiller, S, Maier, T. 登録日 2022-02-03 公開日 2022-09-28 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
7T3H	MicroED structure of Dynobactin 分子名称: TRP-ASN-SER-ASN-VAL-HIS-SER-TYR-ARG-PHE 著者 Yoo, B.-K, Kaiser, J.T, Rees, D.C, Miller, R.D, Iinishi, A, Lewis, K, Bowman, S. 登録日 2021-12-07 公開日 2022-10-19 実験手法 ELECTRON CRYSTALLOGRAPHY (1.05 Å) 主引用文献 Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
6V9F	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 1-[(4-chlorophenyl)methyl]-1H-benzimidazol-2-amine, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9L	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 4-(3-chloro-4-fluorophenoxy)benzene-1-sulfonamide, ACETATE ION, FORMIC ACID, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.698 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
2BD0	Chlorobium tepidum Sepiapterin Reductase complexed with NADP and Sepiapterin 分子名称: BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, sepiapterin reductase 著者 Supangat, S, Seo, K.H, Choi, Y.K, Park, Y.S, Lee, K.H. 登録日 2005-10-19 公開日 2005-11-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin J.Biol.Chem., 281, 2006
2ESB	Crystal structure of human DUSP18 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Dual specificity protein phosphatase 18 著者 Kim, S.J, Ryu, S.E, Jeong, D.G, Cho, Y.H, Yoon, T.S, Kim, J.H. 登録日 2005-10-25 公開日 2006-06-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. Acta Crystallogr.,Sect.D, 62, 2006
7KFZ	Structure of a ternary KRas(G13D)-SOS complex 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Liu, C, Moghadamchargari, Z, Laganowsky, A, Zhao, M. 登録日 2020-10-15 公開日 2021-03-31 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants. Proc.Natl.Acad.Sci.USA, 118, 2021
8Q6P	X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... 著者 Butryn, A, Cvetkovic, M.A, Costa, A. 登録日 2023-08-14 公開日 2023-10-18 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
8Q6O	X. laevis CMG dimer bound to dimeric DONSON - without ATPase 分子名称: Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... 著者 Butryn, A, Cvetkovic, M.A, Costa, A. 登録日 2023-08-14 公開日 2023-10-18 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
6RBC	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a inhibitor KB1157 分子名称: (2~{S})-2-[[(2~{R})-2-[4-[(4-iodophenyl)carbonylamino]butanoylamino]-3-oxidanyl-3-oxidanylidene-propyl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barinka, C, Kutil, Z. 登録日 2019-04-10 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Novel beta- and gamma-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen. J.Med.Chem., 63, 2020
7MSO	Crystal Structure of Polo Box Domain in Complex with Cyclic Peptide Inhibitor 分子名称: Cyclic Peptide Inhibitor ZO1-GLN-SER-TPO-45W-MLL, Serine/threonine-protein kinase PLK1 著者 Lim, D.C, Yaffe, M.B. 登録日 2021-05-11 公開日 2022-03-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1. J.Med.Chem., 65, 2022
6S1X	X-ray structure of human glutamate carboxypeptidase II (GCPII)-E424M inactive mutant, in complex with a inhibitor KB1160 分子名称: (2~{S})-2-[[(3~{S})-3-[3-[(4-iodophenyl)carbonylamino]propanoylamino]-4-oxidanyl-4-oxidanylidene-butyl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barinka, C, Kutil, Z. 登録日 2019-06-19 公開日 2020-05-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Novel beta- and gamma-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen. J.Med.Chem., 63, 2020
5ITS	Crystal structure of LOG from Corynebacterium glutamicum 分子名称: Cytokinin riboside 5'-monophosphate phosphoribohydrolase, GLYCEROL, PHOSPHATE ION 著者 Seo, H.-G, Kim, K.-J. 登録日 2016-03-17 公開日 2016-08-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for cytokinin production by LOG from Corynebacterium glutamicum Sci Rep, 6, 2016
4N45	Crystal structure of reduced form of thiolase from Clostridium acetobutylicum 分子名称: Acetyl-CoA acetyltransferase 著者 Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. 登録日 2013-10-08 公開日 2014-10-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insight into redox-switch regulatory mechanism of thiolase from the n-butanol synthesizing bacterium, Clostridium acetobutylicum to be published
4N44	Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum 分子名称: ACETATE ION, Acetyl-CoA acetyltransferase, GLYCEROL 著者 Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. 登録日 2013-10-08 公開日 2014-10-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structural insight into redox-switch regulatory mechanism of thiolase from the n-butanol synthesizing bacterium, Clostridium acetobutylicum to be published
5JXD	Crystal structure of murine Tnfaip8 C165S mutant 分子名称: Tumor necrosis factor alpha-induced protein 8, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate 著者 Park, J, Kim, M.S, Lee, D, Shin, D.H. 登録日 2016-05-13 公開日 2017-06-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.029 Å) 主引用文献 The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin Sci Rep, 7, 2017
4NYM	Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange 分子名称: GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]-L-tryptophanamide, ... 著者 Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. 登録日 2013-12-10 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5529 Å) 主引用文献 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
4NYJ	Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange 分子名称: GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide, ... 著者 Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. 登録日 2013-12-10 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8522 Å) 主引用文献 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
4NYI	Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange 分子名称: GTPase HRas, MAGNESIUM ION, N-{1-[(5-methyl-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamide, ... 著者 Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. 登録日 2013-12-10 公開日 2014-03-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9612 Å) 主引用文献 Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
7BWL	Structure of antibiotic sequester from Pseudomonas aerurinosa 分子名称: UPF0312 protein PA0423, Ubiquinone-8 著者 Hong, M. 登録日 2020-04-14 公開日 2020-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal structure of the Pseudomonas aeruginosa PA0423 protein and its functional implication in antibiotic sequestration. Biochem.Biophys.Res.Commun., 528, 2020
6V9N	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 4-phenoxybenzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.648 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V94	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 1-[(4-fluorophenyl)methyl]-2-methyl-4-nitro-1H-imidazole, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9J	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 3-(2-aminoethyl)-4-(3-chloro-4-fluorophenoxy)benzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9M	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods 分子名称: 4-fluoro-2-methyl-N-propylbenzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Fesik, S.W. 登録日 2019-12-13 公開日 2020-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.648 Å) 主引用文献 Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020

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