6V9N

Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods

Summary for 6V9N

Entry DOI	10.2210/pdb6v9n/pdb
Descriptor	GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
Functional Keywords	ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	95657.28
Authors	Phan, J.,Fesik, S.W. (deposition date: 2019-12-13, release date: 2020-08-26, Last modification date: 2023-11-15)
Primary citation	Sarkar, D.,Olejniczak, E.T.,Phan, J.,Coker, J.A.,Sai, J.,Arnold, A.,Beesetty, Y.,Waterson, A.G.,Fesik, S.W. Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63:8325-8337, 2020 Cited by PubMed: 32673492 DOI: 10.1021/acs.jmedchem.0c00511 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.648 Å)

Structure validation