7MSO

Crystal Structure of Polo Box Domain in Complex with Cyclic Peptide Inhibitor

Summary for 7MSO

Entry DOI	10.2210/pdb7mso/pdb
Related PRD ID	PRD_002479
Descriptor	Serine/threonine-protein kinase PLK1, Cyclic Peptide Inhibitor ZO1-GLN-SER-TPO-45W-MLL (3 entities in total)
Functional Keywords	phosphopeptide binding domain, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	56247.84
Authors	Lim, D.C.,Yaffe, M.B. (deposition date: 2021-05-11, release date: 2022-03-02, Last modification date: 2023-11-15)
Primary citation	Ryu, S.,Park, J.E.,Ham, Y.J.,Lim, D.C.,Kwiatkowski, N.P.,Kim, D.H.,Bhunia, D.,Kim, N.D.,Yaffe, M.B.,Son, W.,Kim, N.,Choi, T.I.,Swain, P.,Kim, C.H.,Lee, J.Y.,Gray, N.S.,Lee, K.S.,Sim, T. Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1. J.Med.Chem., 65:1915-1932, 2022 Cited by PubMed: 35029981 DOI: 10.1021/acs.jmedchem.1c01359 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation