PDB: 164 件ウェブページステータス検索Chemie searchBIRD

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8FY0	E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) 分子名称: Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... 著者 Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. 登録日 2023-01-25 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
8FY1	E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) 分子名称: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... 著者 Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. 登録日 2023-01-25 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
8FY2	E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) 分子名称: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... 著者 Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. 登録日 2023-01-25 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
8HLL	Crystal structure of p53/BCL2 fusion complex (complex 1) 分子名称: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION 著者 Wei, H, Guo, M, Wang, H, Chen, Y. 登録日 2022-11-30 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HLM	Crystal structure of p53/BCL2 fusion complex (complex 2) 分子名称: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION 著者 Guo, M, Wang, H, Wei, H, Chen, Y. 登録日 2022-11-30 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.522 Å) 主引用文献 Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HLN	Crystal structure of p53/BCL2 fusion complex(complex3) 分子名称: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION 著者 Guo, M, Wei, H, Wang, H, Chen, Y. 登録日 2022-11-30 公開日 2023-07-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.354 Å) 主引用文献 Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
8HOG	Crystal structure of Bcl-2 in complex with sonrotoclax 分子名称: Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 著者 Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. 登録日 2022-12-10 公開日 2024-01-17 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
8HOH	Crystal structure of Bcl-2 G101V in complex with sonrotoclax 分子名称: Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 著者 Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. 登録日 2022-12-10 公開日 2024-01-17 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
8HOI	Crystal structure of Bcl-2 D103Y in complex with sonrotoclax 分子名称: Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 著者 Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. 登録日 2022-12-10 公開日 2024-01-17 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
8IQK	Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins 分子名称: Bcl-2-like protein 1, Bcl-2-modifying factor 著者 Wang, H, Guo, M, Wei, H, Chen, Y. 登録日 2023-03-16 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.879 Å) 主引用文献 Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins. Comput Struct Biotechnol J, 21, 2023
8IQL	Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins 分子名称: Apoptosis regulator Bcl-2, Bcl-2-modifying factor 著者 Wang, H, Guo, M, Wei, H, Chen, Y. 登録日 2023-03-16 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9577 Å) 主引用文献 Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins. Comput Struct Biotechnol J, 21, 2023
8U27	Bcl-2-xL complexed with compound 35 分子名称: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate 著者 Rizo, J, Pan, Y.-Z. 登録日 2023-09-05 公開日 2023-09-13 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insights for selective disruption of Beclin 1 binding to Bcl-2. Commun Biol, 6, 2023
8WLS	Bcl-xL in complex with HBx BH3 delta C peptide 分子名称: Bcl-2-like protein 1, Protein X 著者 Kobayashi, N, Nagata, T, Kusunoki, H. 登録日 2023-10-01 公開日 2024-03-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Insights into the Interaction between the C-Terminal-Deleted BH3-like Motif Peptide of Hepatitis B Virus X Protein and Bcl-x L. Biochemistry, 63, 2024
8XP5	The Crystal Structure of p53/BCL-xL fusion complex from Biortus. 分子名称: Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. 登録日 2024-01-03 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The Crystal Structure of p53/BCL-xL fusion complex from Biortus. To Be Published

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