PDB: 238 件ウェブページステータス検索Chemie searchBIRD

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3W2K	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-165 分子名称: 5-[2-(4-fluoro-3-methylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-29 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-165 To be Published
3W2L	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-169 分子名称: 5-[2-(4-methoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-29 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-169 To be Published
3W2J	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-135 分子名称: 5-[2-(3,4-difluorophenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-28 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-135 To be Published
3W2M	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-183 分子名称: 2,6-dioxo-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-30 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-183. To be Published
3W1X	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121 分子名称: 5-{2-[4-(cyanomethyl)phenyl]ethyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-22 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-121. To be Published
3W23	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-131 分子名称: 5-[2-(3-chlorophenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-26 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-131 To be Published
3W22	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 分子名称: 5-[2-(4-tert-butylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-26 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 To be Published
3W1T	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-095 分子名称: 2,6-dioxo-5-{2-[3-(trifluoromethyl)phenyl]ethyl}-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-21 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-095 To be Published
3W1U	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-111 分子名称: 5-[2-(4-methylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-21 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-111 To be Published
3W1N	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-iodoorotate 分子名称: 5-iodo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-19 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-iodoorotate To be Published
3W1L	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-chloroorotate 分子名称: 5-chloro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-16 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-chloroorotate TO BE PUBLISHED
3W1P	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-ethenyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid 分子名称: 5-ethenyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-19 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-ethenyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid To be Published
3W1M	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-bromoorotate 分子名称: 5-bromo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A. 登録日 2012-11-16 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-bromoorotate To be Published
3W1R	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-045a 分子名称: 2,6-dioxo-5-(2-phenylethyl)-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-20 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-045a To be Published
3W1Q	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with NL-2 分子名称: 5-(3,3-dimethylbutyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-20 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with NL-2 To be Published
3W1A	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-13 公開日 2013-11-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives To be Published
4IGH	High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog 分子名称: 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, 6-fluoro-2-[2-methyl-4-phenoxy-5-(propan-2-yl)phenyl]quinoline-4-carboxylic acid, Dihydroorotate dehydrogenase (quinone), ... 著者 Deng, X, Das, P, Fontoura, B.M.A, Phillips, M.A, De Brabander, J.K. 登録日 2012-12-17 公開日 2013-08-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. ACS MED.CHEM.LETT., 4, 2013
4EF9	Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Pinheiro, M.P, Emery, F.S, Nonato, M.C. 登録日 2012-03-29 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
4EF8	Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Pinheiro, M.P, Emery, F.S, Nonato, M.C. 登録日 2012-03-29 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
3TJX	Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant H174A 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 de Souza, A.L, Nonato, M.C, Pinheiro, M.P. 登録日 2011-08-25 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant H174A To be Published
3TRO	Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 de Souza, A.L, Pinheiro, M.P, Nonato, M.C. 登録日 2011-09-09 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A To be Published
3ZWT	Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor 分子名称: 2-{[(2,5-DICHLOROPHENYL)METHYL]SULFANYL}-5-ETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL, ACETATE ION, CHLORIDE ION, ... 著者 Acklam, P.A, Parsons, M.R. 登録日 2011-08-02 公開日 2012-06-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases. J.Med.Chem., 55, 2012
3ZWS	Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor 分子名称: 2-[(2,5-DICHLOROBENZYL)SULFANYL]-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL, ACETATE ION, CHLORIDE ION, ... 著者 Acklam, P.A, Parsons, M.R. 登録日 2011-08-02 公開日 2012-06-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases. J.Med.Chem., 55, 2012
3TQ0	Crystal structure of Leishmania major dihydroorotate dehydrogenase in complex with fumarate 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, FUMARIC ACID, ... 著者 Cordeiro, A.T, Feliciano, P.R, Nonato, M.C. 登録日 2011-09-08 公開日 2012-05-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of dihydroorotate dehydrogenase from Leishmania major. Biochimie, 94, 2012
3U2O	Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor 分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Lozoya, E, Segarra, V, Erra, M, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M. 登録日 2011-10-04 公開日 2011-11-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Biaryl analogues of teriflunomide as potent DHODH inhibitors. Bioorg.Med.Chem.Lett., 21, 2011

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