4IGH

High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

Summary for 4IGH

Entry DOI	10.2210/pdb4igh/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywords	anti-viral, quinoline-4-carboxylic acid, redox, dehydrogenase, fmn, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	42143.88
Authors	Deng, X.,Das, P.,Fontoura, B.M.A.,Phillips, M.A.,De Brabander, J.K. (deposition date: 2012-12-17, release date: 2013-08-21, Last modification date: 2023-09-20)
Primary citation	Das, P.,Deng, X.,Zhang, L.,Roth, M.G.,Fontoura, B.M.,Phillips, M.A.,De Brabander, J.K. SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. ACS MED.CHEM.LETT., 4:517-521, 2013 Cited by PubMed: 23930152 DOI: 10.1021/ml300464h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation