4IGH
High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 372 | 40624.3 | 1 | UniProt (Q02127) Pfam (PF01180) | Homo sapiens (human) | DHOdehase, Dihydroorotate oxidase |
| 2 | B (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | C (A) | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 4 | D (A) | 6-fluoro-2-[2-methyl-4-phenoxy-5-(propan-2-yl)phenyl]quinoline-4-carboxylic acid | non-polymer | 415.5 | 1 | Chemie (1EA) | |||
| 5 | E (A) | 3-[decyl(dimethyl)ammonio]propane-1-sulfonate | non-polymer | 307.5 | 1 | Chemie (ZWI) | |||
| 6 | F, G (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | H (A) | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A: 33 - 396 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| Leu 397 | - | expression tag |
| Glu 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
| His 401 | - | expression tag |
| His 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40624.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1519.6 | |
| All* | Total formula weight | 42143.9 |
