3U2O

Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor

Summary for 3U2O

DescriptorDihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywordsdhodh, dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion inner membrane; Single-pass membrane protein Q02127
Total number of polymer chains1
Total molecular weight44279.26
Authors
Lozoya, E.,Segarra, V.,Erra, M.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M. (deposition date: 2011-10-04, release date: 2011-11-16, Last modification date: 2012-09-05)
Primary citation
Erra, M.,Moreno, I.,Sanahuja, J.,Andres, M.,Reinoso, R.F.,Lozoya, E.,Pizcueta, P.,Godessart, N.,Castro-Palomino, J.C.
Biaryl analogues of teriflunomide as potent DHODH inhibitors.
Bioorg.Med.Chem.Lett., 21:7268-7272, 2011
PubMed: 22078215 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2011.10.052
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.18 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.211402.7%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
167518
PDB entries from 2020-08-12