3ZWS
Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor
Summary for 3ZWS
Entry DOI | 10.2210/pdb3zws/pdb |
Related | 1D3G 1D3H 2B0M 2BXV 2WV8 3ZWT |
Descriptor | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion inner membrane; Single-pass membrane protein: Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 41155.86 |
Authors | Acklam, P.A.,Parsons, M.R. (deposition date: 2011-08-02, release date: 2012-06-27, Last modification date: 2024-05-08) |
Primary citation | Bedingfield, P.T.P.,Cowen, D.,Acklam, P.A.,Cunningham, F.,Parsons, M.R.,Mcconkey, G.A.,Fishwick, C.W.G.,Johnson, A.P. Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases. J.Med.Chem., 55:5841-, 2012 Cited by PubMed: 22621375DOI: 10.1021/JM300157N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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