5NO6
 
 | | TEAD4-HOXB13 complex bound to DNA | | 分子名称: | DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3 | | 著者 | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | | 登録日 | 2017-04-11 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | TEAD4-HOXB13 complex bound to DNA
To Be Published
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5ZJQ
 | | Structure of AbdB/Exd complex bound to a 'Red14' DNA sequence | | 分子名称: | DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), Homeobox protein abdominal-B, ... | | 著者 | Baburajendran, N, Zeiske, T, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G. | | 登録日 | 2018-03-22 | | 公開日 | 2018-08-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.443 Å) | | 主引用文献 | Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
Cell Rep, 24, 2018
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4UUS
 | | CRYSTAL STRUCTURE OF A UBX-EXD-DNA COMPLEX INCLUDING THE UBDA MOTIF | | 分子名称: | 5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3', HOMEOTIC PROTEIN EXTRADENTICLE, ... | | 著者 | Foos, N, Mate, M.J, Ortiz-Lombardia, M. | | 登録日 | 2014-07-31 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode.
Structure, 23, 2015
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8SPS
 | | High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b | | 分子名称: | DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | | 著者 | Lian, T, Guan, R, Bai, Y. | | 登録日 | 2023-05-03 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
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8SPU
 | | Structure of ESRRB nucleosome bound OCT4 at site c | | 分子名称: | DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | | 著者 | Lian, T, Guan, R, Bai, Y. | | 登録日 | 2023-05-03 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
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7U0G
 | | structure of LIN28b nucleosome bound 3 OCT4 | | 分子名称: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | | 著者 | Lian, T, Guan, R, Bai, Y. | | 登録日 | 2022-02-18 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
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7U0I
 | | Structure of LIN28b nucleosome bound 2 OCT4 | | 分子名称: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | | 著者 | Tengfei, L, Guan, R, Bai, Y. | | 登録日 | 2022-02-18 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4.
Mol.Cell, 83, 2023
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8T0F
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8T11
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2XSD
 | | Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA | | 分子名称: | 1,2-ETHANEDIOL, 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*AP)-3', 5'-D(*CP*CP*TP*CP*AP*TP*GP*CP*AP*TP*AP)-3', ... | | 著者 | Jauch, R, Choo, S.H, Ng, C.K.L, Kolatkar, P.R. | | 登録日 | 2010-09-28 | | 公開日 | 2010-10-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA.
Proteins, 79, 2011
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3L1P
 | | POU protein:DNA complex | | 分子名称: | DNA (5'-D(*AP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP*TP*CP*AP*AP*AP*TP*GP*TP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP*CP*AP*AP*AP*TP*GP*GP*A)-3'), POU domain, ... | | 著者 | Vahokoski, J, Groves, M.R, Pogenberg, V, Wilmanns, M. | | 登録日 | 2009-12-14 | | 公開日 | 2010-12-15 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A unique Oct4 interface is crucial for reprogramming to pluripotency
Nat.Cell Biol., 15, 2013
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6T90
 | | OCT4-SOX2-bound nucleosome - SHL-6 | | 分子名称: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2019-10-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
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4XRS
 | | Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA | | 分子名称: | DNA (5'-D(P*AP*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*TP*T)-3'), ... | | 著者 | Jorma, A, Yin, Y, Nitta, K.R, Dave, K, Enge, M, Kivioja, T, Popov, A, Morgunova, E, Taipale, J. | | 登録日 | 2015-01-21 | | 公開日 | 2015-11-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | DNA-dependent formation of transcription factor pairs alters their binding specificity.
Nature, 527, 2015
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4S0H
 | | TBX5 DB, NKX2.5 HD, ANF DNA Complex | | 分子名称: | 5'-D(*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP*GP*TP*GP*AP*GP*A)-3', 5'-D(*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP*TP*GP*AP*AP*GP*TP*GP*G)-3', Homeobox protein Nkx-2.5, ... | | 著者 | Pradhan, L. | | 登録日 | 2014-12-31 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.817 Å) | | 主引用文献 | Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5.
Biochemistry, 55, 2016
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6WC2
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1CQT
 | | CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT | | 分子名称: | DNA (5'-D(*AP*CP*CP*TP*TP*AP*TP*TP*TP*GP*CP*AP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*CP*AP*AP*AP*TP*AP*AP*GP*G)-3'), POU DOMAIN, ... | | 著者 | Chasman, D.I, Cepek, K, Sharp, P.A, Pabo, C.O. | | 登録日 | 1999-08-11 | | 公開日 | 1999-11-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.
Genes Dev., 13, 1999
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1E3O
 | | Crystal structure of Oct-1 POU dimer bound to MORE | | 分子名称: | 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1 | | 著者 | Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M. | | 登録日 | 2000-06-20 | | 公開日 | 2001-11-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping
Mol.Cell, 8, 2001
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6WC5
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6YOV
 | | OCT4-SOX2-bound nucleosome - SHL+6 | | 分子名称: | DNA (142-MER), Green fluorescent protein,POU domain, class 5, ... | | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2020-04-15 | | 公開日 | 2020-05-06 | | 最終更新日 | 2020-07-08 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
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8BX1
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8BX2
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3D1N
 | | Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter | | 分子名称: | 5'-D(*DAP*DGP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DA)-3', 5'-D(*DTP*DTP*DAP*DTP*DTP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DCP*DT)-3', POU domain, ... | | 著者 | Pereira, J.H, Ha, S.C, Kim, S.-H. | | 登録日 | 2008-05-06 | | 公開日 | 2009-05-26 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structure of human Brn-5 transcription factor in complex with CRH gene promoter.
J.Struct.Biol., 167, 2009
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5FLV
 | | Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region | | 分子名称: | 5'-D(*AP*CP*CP*AP*CP*TP*TP*CP*AP*AP*AP*GP*GP*TP *GP*TP*GP*AP*GP*AP*AP*G)-3', 5'-D(*TP*CP*TP*TP*CP*TP*CP*AP*CP*AP*CP*CP*TP*TP *TP*GP*AP*AP*GP*TP*GP*G)-3', HOMEOBOX PROTEIN NKX-2.5, ... | | 著者 | Stirnimann, C.U, Glatt, S, Mueller, C.W. | | 登録日 | 2015-10-28 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.005 Å) | | 主引用文献 | Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Cell(Cambridge,Mass.), 164, 2016
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5EGO
 | | HOXB13-MEIS1 heterodimer bound to methylated DNA | | 分子名称: | DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), Homeobox protein Hox-B13, ... | | 著者 | Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. | | 登録日 | 2015-10-27 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science, 356, 2017
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1MNM
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