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6HQ7
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Structure of EAL Enzyme Bd1971 - cGMP bound form
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION
著者Lovering, A.L, Cadby, I.T.
登録日2018-09-24
公開日2019-07-31
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
4BYY
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BU of 4byy by Molmil
Apo GlxR
分子名称: GLYCEROL, PHOSPHATE ION, TRANSCRIPTIONAL REGULATOR, ...
著者Pohl, E, Cann, M.J, Townsend, P.D, Money, V.A.
登録日2013-07-21
公開日2014-07-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献The Crystal Structures of Apo and Camp-Bound Glxr from Corynebacterium Glutamicum Reveal Structural and Dynamic Changes Upon Camp Binding in Crp/Fnr Family Transcription Factors.
Plos One, 9, 2014
3OCP
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BU of 3ocp by Molmil
Crystal structure of cAMP bound cGMP-dependent protein kinase(92-227)
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PRKG1 protein
著者Kim, J.J, Huang, G, Kwon, T.K, Zwart, P, Headd, J, Kim, C.
登録日2010-08-10
公開日2011-05-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011
3U11
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Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
著者Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
登録日2011-09-29
公開日2011-10-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
2QVS
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BU of 2qvs by Molmil
Crystal Structure of Type IIa Holoenzyme of cAMP-dependent Protein Kinase
分子名称: cAMP-dependent protein kinase type II-alpha regulatory subunit, cAMP-dependent protein kinase, alpha-catalytic subunit
著者Wu, J, Brown, S.H.J, von Daake, S, Taylor, S.S.
登録日2007-08-08
公開日2007-10-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science, 318, 2007
4JVA
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BU of 4jva by Molmil
Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog
分子名称: (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, cAMP-dependent protein kinase type II-beta regulatory subunit
著者Brown, S.H.J, Cheng, C.Y, Saldanha, A.S, Wu, J, Cottam, H, Sankaran, B, Taylor, S.S.
登録日2013-03-25
公開日2013-09-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.
Acs Chem.Biol., 8, 2013
1O7F
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BU of 1o7f by Molmil
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2
分子名称: CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR
著者Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A.
登録日2002-11-04
公開日2002-11-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and Regulation of the Camp-Binding Domains of Epac2
Nat.Struct.Biol., 10, 2002
1J59
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CATABOLITE GENE ACTIVATOR PROTEIN (CAP)/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
分子名称: 5'-D(*AP*TP*AP*TP*GP*TP*CP*AP*CP*AP*CP*TP*TP*TP*TP*CP*G )-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*GP*TP*GP*TP*GP*AP*C)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
著者Parkinson, G, Wilson, C, Gunasekera, A, Ebright, Y.W, Ebright, R.H, Berman, H.M.
登録日2002-03-01
公開日2002-03-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface.
J.Mol.Biol., 260, 1996
6WEL
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BU of 6wel by Molmil
Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs
分子名称: 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ...
著者Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J.
登録日2020-04-02
公開日2020-06-03
最終更新日2020-07-22
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Nat.Struct.Mol.Biol., 27, 2020
4NVP
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BU of 4nvp by Molmil
Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP
分子名称: (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
著者Alfieri, A, Moroni, A.
登録日2013-12-05
公開日2014-03-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
4Z07
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BU of 4z07 by Molmil
Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, ISOPROPYL ALCOHOL, SULFATE ION, ...
著者Kim, J.J, Reger, A.S, Arold, S.T, Kim, C.
登録日2015-03-25
公開日2016-04-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
Structure, 24, 2016
3SHR
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BU of 3shr by Molmil
Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cGMP-dependent protein kinase 1
著者Osborne, B.W, Wu, J, Taylor, S.S, Dostmann, W.R.
登録日2011-06-16
公開日2011-09-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication.
Structure, 19, 2011
5EZR
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BU of 5ezr by Molmil
Crystal Structure of PVX_084705 bound to compound
分子名称: CHLORIDE ION, N-[5-(3-{2-[(cyclopropylmethyl)amino]pyrimidin-4-yl}-7-[(dimethylamino)methyl]-6-methylimidazo[1,2-a]pyridin-2-yl)-2-fluorophenyl]methanesulfonamide, cGMP-dependent protein kinase, ...
著者El Bakkouri, M, Amani, M, Walker, J.R, Osborne, S, Large, J.M, Birchall, K, Bouloc, N, Smiljanic-Hurley, E, Wheldon, M, Harding, D.J, Merritt, A.T, Ansell, K.H, Coombs, P.J, Kettleborough, C.A, Stewart, B.L, Bowyer, P.W, Gutteridge, W.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Baker, D.A, Hui, R, Loppnau, P, Structural Genomics Consortium (SGC)
登録日2015-11-26
公開日2017-05-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of PVX_084705 bound to compound
To Be Published
4X6Q
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BU of 4x6q by Molmil
An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes
分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit
著者Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Taylor, S.S.
登録日2014-12-08
公開日2015-07-22
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
8EM8
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BU of 8em8 by Molmil
Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165
分子名称: UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ...
著者Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2022-09-27
公開日2022-11-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165
To Be Published
4D7S
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BU of 4d7s by Molmil
Structure of the SthK Carboxy-Terminal Region in complex with cGMP
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, STHK_CNBD_CGMP
著者Kesters, D, Brams, M, Nys, M, Wijckmans, E, Spurny, R, Voets, T, Tytgat, J, Ulens, C.
登録日2014-11-27
公開日2015-02-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels.
Plos One, 10, 2015
4L11
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BU of 4l11 by Molmil
Structure of the C-linker/CNBHD of agERG channels
分子名称: AGAP007709-PA
著者Brelidze, T.I.
登録日2013-06-01
公開日2013-06-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of the C-terminal region of an ERG channel and functional implications.
Proc.Natl.Acad.Sci.USA, 110, 2013
3DV8
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BU of 3dv8 by Molmil
Crystal structure of a putative transcriptional regulator of the crp/fnr family (eubrec_1222) from eubacterium rectale atcc 33656 at 2.55 A resolution
分子名称: transcriptional regulator, Crp/Fnr family
著者Joint Center for Structural Genomics (JCSG)
登録日2008-07-18
公開日2008-08-05
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of transcriptional regulator, Crp/Fnr family (RER070207001219) from Eubacterium rectale at 2.55 A resolution
To be published
4D7T
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BU of 4d7t by Molmil
Structure of the SthK Carboxy-Terminal Region in complex with cAMP
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, STHK_CNBD_CAMP
著者Kesters, D, Brams, M, Nys, M, Wijckmans, E, Spurny, R, Voets, T, Tytgat, J, Ulens, C.
登録日2014-11-27
公開日2015-02-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.582 Å)
主引用文献Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels.
Plos One, 10, 2015
7LFT
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BU of 7lft by Molmil
Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+
分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, POTASSIUM ION, ...
著者Xue, J, Han, Y, Jiang, Y.
登録日2021-01-18
公開日2021-03-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
Neuron, 109, 2021
4F7Z
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Conformational dynamics of exchange protein directly activated by cAMP
分子名称: GLYCEROL, Rap guanine nucleotide exchange factor 4
著者White, M.A, Tsalkova, T.N, Mei, F.C, Liu, T, Woods, V.L, Cheng, X.
登録日2012-05-16
公開日2012-10-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.
Plos One, 7, 2012
3LA2
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BU of 3la2 by Molmil
Crystal structure of NtcA in complex with 2-oxoglutarate
分子名称: 2-OXOGLUTARIC ACID, Global nitrogen regulator
著者Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z.
登録日2010-01-06
公開日2010-07-14
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.
Proc.Natl.Acad.Sci.USA, 107, 2010
5CVR
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BU of 5cvr by Molmil
Crystal structure of FNR of A. fischeri in a partially degraded form
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, FE2/S2 (INORGANIC) CLUSTER, FNR type regulator
著者Volbeda, A, Fontecilla-Camps, J.C.
登録日2015-07-27
公開日2015-12-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium.
Sci Adv, 1, 2015
4HBN
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Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
著者Xu, X, Marni, F, Wu, X, Su, Z, Musayev, F, Shrestha, S, Xie, C, Gao, W, Liu, Q, Zhou, L.
登録日2012-09-28
公開日2013-01-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Local and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel.
Structure, 20, 2012
6NP6
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Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis
分子名称: Crp/Fnr family transcriptional regulator, GLYCEROL
著者Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Scarsdale, J.N, Lewis, J.P.
登録日2019-01-17
公開日2019-06-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019

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