3OCP

Crystal structure of cAMP bound cGMP-dependent protein kinase(92-227)

Summary for 3OCP

• Entry DOI: 10.2210/pdb3ocp/pdb
• Related: 3OD0 3OGJ
• Descriptor: PRKG1 protein, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (3 entities in total)
• Functional Keywords: serine/threonine kinase, tf2i and irag, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 31872.77

Authors

Kim, J.J.,Huang, G.,Kwon, T.K.,Zwart, P.,Headd, J.,Kim, C. (deposition date: 2010-08-10, release date: 2011-05-11, Last modification date: 2023-09-06)

Primary citation

Kim, J.J.,Casteel, D.E.,Huang, G.,Kwon, T.H.,Ren, R.K.,Zwart, P.,Headd, J.J.,Brown, N.G.,Chow, D.C.,Palzkill, T.,Kim, C.
Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6:e18413-e18413, 2011

PubMed Abstract: Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation. As one of the main receptors for cGMP, PKGs mediate most of the effects of cGMP elevating drugs, such as nitric oxide-releasing agents and phosphodiesterase inhibitors which are used for the treatment of angina pectoris and erectile dysfunction, respectively.

PubMed: 21526164
DOI: 10.1371/journal.pone.0018413

Experimental method

X-RAY DIFFRACTION (2.49 Å)