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6B6H
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The cryo-EM structure of a bacterial class I transcription activation complex
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A.
登録日2017-10-02
公開日2017-11-15
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis of bacterial transcription activation.
Science, 358, 2017
5W5B
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Crystal structure of Mycobacterium tuberculosis CRP-FNR family transcription factor Cmr (Rv1675c), truncated construct
分子名称: CHLORIDE ION, HTH-type transcriptional regulator Cmr
著者Cheung, J, Cassidy, M, Ginter, C, Ranganathan, S, Pata, D.J, McDonough, K.A.
登録日2017-06-14
公開日2017-12-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria.
Nucleic Acids Res., 46, 2018
5W5A
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Crystal structure of Mycobacterium tuberculosis CRP-FNR family transcription factor Cmr (Rv1675c)
分子名称: CHLORIDE ION, HTH-type transcriptional regulator Cmr, SULFATE ION
著者Cheung, J, Cassidy, M, Ginter, C, Ranganathan, S, Pata, D.J, McDonough, K.A.
登録日2017-06-14
公開日2017-12-13
最終更新日2019-01-09
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Novel structural features drive DNA binding properties of Cmr, a CRP family protein in TB complex mycobacteria.
Nucleic Acids Res., 46, 2018
5VA3
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Cryo-EM structure of the human ether-a-go-go related K+ channel
分子名称: Potassium voltage-gated channel subfamily H member 2
著者Wang, W.W, MacKinnon, R.
登録日2017-03-24
公開日2017-05-03
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5VA2
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Cryo-EM structure of the human ether-a-go-go related K+ channel
分子名称: Potassium voltage-gated channel subfamily H member 2
著者Wang, W.W, MacKinnon, R.
登録日2017-03-24
公開日2017-05-03
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5VA1
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Cryo-EM structure of the human ether-a-go-go related K+ channel
分子名称: Potassium voltage-gated channel subfamily H member 2
著者Wang, W.W, MacKinnon, R.
登録日2017-03-24
公開日2017-05-03
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5V4S
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CryoEM Structure of a Prokaryotic Cyclic Nucleotide-Gated Ion Channel
分子名称: Transporter, cation channel family / cyclic nucleotide-binding domain multi-domain protein
著者James, Z.M, Borst, A.J, Haitin, Y, Frenz, B, DiMaio, F, Zagotta, W.N, Veesler, D.
登録日2017-03-10
公開日2017-04-12
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V30
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Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis
分子名称: GLYCEROL, SULFATE ION, Transcriptional regulator
著者Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Lewis, J.P.
登録日2017-03-06
公開日2018-06-13
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
5U6P
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Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11
著者Lee, C.-H, MacKinnon, R.
登録日2016-12-08
公開日2017-01-25
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.51 Å)
主引用文献Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell, 168, 2017
5U6O
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Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel
分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
著者Lee, C.-H, MacKinnon, R.
登録日2016-12-08
公開日2017-01-25
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell, 168, 2017
5T3N
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Sp-2Cl-cAMPS bound to PKAR CBD2
分子名称: (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit
著者Littler, D.R, Gilson, P.
登録日2016-08-26
公開日2016-10-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
5L0N
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PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with RP-cGMP
分子名称: 1,2-ETHANEDIOL, 2-amino-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidenetetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ...
著者Campbell, J.C, Sankaran, B, Kim, C.W.
登録日2016-07-27
公開日2017-08-02
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.285 Å)
主引用文献Structure of PKG I CNB-B bound to RP-cGMP
To Be Published
5KJZ
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Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit
著者Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W.
登録日2016-06-20
公開日2017-06-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.347 Å)
主引用文献Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
Biochem. J., 474, 2017
5KJY
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Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cAMP
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit
著者Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W.
登録日2016-06-20
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
Biochem. J., 474, 2017
5KJX
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Co-crystal Structure of PKA RI alpha CNB-B domain with cAMP
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit
著者Lorenz, R, Moon, E, Kim, J.J, Huang, G.Y, Kim, C, Herberg, F.W.
登録日2016-06-20
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
Biochem. J., 474, 2017
5KHK
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HCN2 CNBD in complex with 2-aminopurine riboside-3', 5'-cyclic monophosphate (2-NH2-cPuMP)
分子名称: 2-Aminopurine riboside-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHJ
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HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP)
分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Uridine-3',5'-cyclic monophosphate
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHI
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HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP)
分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Purine riboside-3',5'-cyclic monophosphate
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHH
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HCN2 CNBD in complex with inosine-3', 5'-cyclic monophosphate (cIMP)
分子名称: Inosine-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KHG
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HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP)
分子名称: 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.241 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
5KBF
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cAMP bound PfPKA-R (141-441)
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit, putative
著者Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J.
登録日2016-06-03
公開日2016-10-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
5K8S
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cAMP bound PfPKA-R (297-441)
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP-dependent protein kinase regulatory subunit
著者Littler, D.R, Gilson, P.R, Crabb, B.S, Rossjohn, J.J.
登録日2016-05-31
公開日2016-10-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
5K7L
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Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 bound to the channel inhibitor calmodulin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calmodulin, ...
著者Whicher, J.R, MacKinnon, R.
登録日2016-05-26
公開日2016-08-17
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism.
Science, 353, 2016
5JR7
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Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA
分子名称: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit
著者Bruystens, J.G.H, Wu, J, Taylor, S.S.
登録日2016-05-05
公開日2017-03-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.56 Å)
主引用文献Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation.
J. Mol. Biol., 428, 2016
5JON
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Crystal structure of the unliganded form of HCN2 CNBD
分子名称: Maltose-binding periplasmic protein,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, NITRATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Klenchin, V.A, Chanda, B.
登録日2016-05-02
公開日2016-11-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.042 Å)
主引用文献Structure and dynamics underlying elementary ligand binding events in human pacemaking channels.
Elife, 5, 2016

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