7K1N
 
 | | CryoEM structure of inactivated-form DNA-PK (Complex V) | | 分子名称: | DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | | 著者 | Chen, X, Gellert, M, Yang, W. | | 登録日 | 2020-09-08 | | 公開日 | 2021-01-06 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
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7K1K
 | | CryoEM structure of inactivated-form DNA-PK (Complex IV) | | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | | 著者 | Chen, X, Gellert, M, Yang, W. | | 登録日 | 2020-09-07 | | 公開日 | 2021-01-06 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ.
Mol.Cell, 81, 2021
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6ZH2
 | | Cryo-EM structure of DNA-PKcs (State 1) | | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs | | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2020-06-20 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
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6ZH8
 | | Cryo-EM structure of DNA-PKcs:DNA | | 分子名称: | DNA (5'-D(P*AP*CP*TP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*T)-3'), DNA-dependent protein kinase catalytic subunit,DNA-PKcs | | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2020-06-21 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
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5Y3R
 | | Cryo-EM structure of Human DNA-PK Holoenzyme | | 分子名称: | DNA (34-MER), DNA (36-MER), DNA-dependent protein kinase catalytic subunit, ... | | 著者 | Yin, X, Liu, M, Tian, Y, Wang, J, Xu, Y. | | 登録日 | 2017-07-29 | | 公開日 | 2017-09-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Cryo-EM structure of human DNA-PK holoenzyme
Cell Res., 27, 2017
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6ZFP
 | | Cryo-EM structure of DNA-PKcs (State 2) | | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs | | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2020-06-17 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
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6ZH6
 | | Cryo-EM structure of DNA-PKcs:Ku80ct194 | | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5 | | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2020-06-21 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
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6ZH4
 | | Cryo-EM structure of DNA-PKcs (State 3) | | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs | | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2020-06-20 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
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6WH2
 | | Structure of the C-terminal BRCT domain of human XRCC1 | | 分子名称: | X-ray repair cross complementing protein 1 variant | | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | | 登録日 | 2020-04-07 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.414 Å) | | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
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8P26
 | | Crystal structure of Arabidopsis thaliana PAXX | | 分子名称: | U2 small nuclear ribonucleoprotein auxiliary factor-like protein | | 著者 | Ochi, T. | | 登録日 | 2023-05-15 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Plant PAXX has an XLF-like function and stimulates DNA end joining by the Ku-DNA ligase IV/XRCC4 complex.
Plant J., 116, 2023
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8UCI
 | | Thermophilic RNA Ligase from Palaeococcus pacificus K238G + AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | | 登録日 | 2023-09-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.
Nucleic Acids Res., 52, 2024
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8UCG
 | | Thermophilic RNA Ligase from Palaeococcus pacificus K92A | | 分子名称: | ATP dependent DNA ligase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | | 登録日 | 2023-09-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.
Nucleic Acids Res., 52, 2024
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8UCF
 | | Thermophilic RNA Ligase from Palaeococcus pacificus K238G | | 分子名称: | ATP dependent DNA ligase, GLYCEROL, MAGNESIUM ION | | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | | 登録日 | 2023-09-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.
Nucleic Acids Res., 52, 2024
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8UCH
 | | Thermophilic RNA Ligase from Palaeococcus pacificus K92A + ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | | 登録日 | 2023-09-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.
Nucleic Acids Res., 52, 2024
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8UCE
 | | Thermophilic RNA Ligase from Palaeococcus pacificus + AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | | 登録日 | 2023-09-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.
Nucleic Acids Res., 52, 2024
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5W1R
 | | Cryo-EM structure of DNAPKcs | | 分子名称: | DNA-dependent protein kinase catalytic subunit | | 著者 | Sharif, H, Li, Y, Wu, H. | | 登録日 | 2017-06-04 | | 公開日 | 2017-07-19 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-EM structure of the DNA-PK holoenzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7OTP
 | | DNA-PKcs in complex with ATPgammaS-Mg | | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Liang, S, Thomas, S.E, Blundell, T.L. | | 登録日 | 2021-06-10 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs.
Nature, 601, 2022
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7K11
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8EZ9
 | | Dimeric complex of DNA-PKcs | | 分子名称: | DNA-dependent protein kinase catalytic subunit, unknown region of DNA-PKcs | | 著者 | Chen, S, He, Y. | | 登録日 | 2022-10-31 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (5.67 Å) | | 主引用文献 | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Sci Adv, 9, 2023
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7K19
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7K1B
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7K10
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3N9B
 | | Crystal Structure of the P. aeruginosa LigD phosphoesterase domain | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | | 著者 | Shuman, S, Nair, P, Smith, P. | | 登録日 | 2010-05-28 | | 公開日 | 2010-08-11 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily
Proc.Natl.Acad.Sci.USA, 107, 2010
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3N9D
 | | Monoclinic Structure of P. aeruginosa LigD phosphoesterase domain | | 分子名称: | MANGANESE (II) ION, Probable ATP-dependent DNA ligase, SULFATE ION, ... | | 著者 | Shuman, S, Nair, P, Smith, P. | | 登録日 | 2010-05-28 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily
Proc.Natl.Acad.Sci.USA, 107, 2010
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3TA5
 | | Cobalt bound structure of an archaeal member of the LigD 3'-phosphoesterase DNA repair enzyme family | | 分子名称: | ATP-dependent DNA ligase, N-terminal domain protein, COBALT (II) ION, ... | | 著者 | Das, U, Smith, P, Shuman, S. | | 登録日 | 2011-08-03 | | 公開日 | 2011-10-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Structural insights to the metal specificity of an archaeal member of the LigD 3'-phosphoesterase DNA repair enzyme family.
Nucleic Acids Res., 40, 2012
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