PDB: 13413 件ウェブページステータス検索Chemie searchBIRD

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6IPD	Post-catalytic Complex of Human DNA Polymerase Mu with Templating Adenine and Mn-8oxodGMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
6IPI	Binary Complex of Human DNA Polymerase Mu with MndCTP 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
7EKJ	Crystals structure of classical swine fever virus NS5B (residues 91-694) 分子名称: Classical swine fever virus NS5B 著者 Liu, W, Gong, P. 登録日 2021-04-05 公開日 2021-07-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase. Nucleic Acids Res., 49, 2021
6IPF	Post-catalytic Complex of Human DNA Polymerase Mu with Templating Cytosine and Mn-8oxodGMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
6IPL	Binary Complex of Human DNA Polymerase Mu with MgdATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MAGNESIUM ION, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
1Z4U	hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585 分子名称: (2Z)-2-[(1-ADAMANTYLCARBONYL)AMINO]-3-[4-(2-BROMOPHENOXY)PHENYL]PROP-2-ENOIC ACID, CHLORIDE ION, GLYCEROL, ... 著者 Pfefferkorn, J.A, Greene, M, Nugent, R, Gross, R.J, Mitchell, M.A, Finzel, B.C, Harris, M.S, Wells, P.A, Shelly, J.A, Anstadt, R. 登録日 2005-03-16 公開日 2005-06-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid Bioorg.Med.Chem.Lett., 15, 2005
7P6X	Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 分子名称: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 著者 Llorca, O, Serna, M, Fernandez-Leiro, R. 登録日 2021-07-18 公開日 2021-12-15 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res., 50, 2022
5W1T	X-ray crystal structure of Escherichia coli RNA polymerase and DksA complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2017-06-04 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
4YGX	Crystal Structure of D. melanogaster Ssu72+Symplekin bound to cis peptidomimetic CTD phospho-Ser5 peptide 分子名称: LD40846p, Symplekin, cis peptidomimetic CTD phospho-Ser5 peptide 著者 Mayfield, J.E, Zhang, Y. 登録日 2015-02-26 公開日 2015-09-16 最終更新日 2015-10-28 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. Acs Chem.Biol., 10, 2015
8GZR	Cryo-EM structure of the the NS5-NS3 RNA-elongation complex 分子名称: CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... 著者 Osawa, T, Ehara, H, Sekine, S. 登録日 2022-09-27 公開日 2023-08-02 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
6IPE	Post-catalytic Complex of Human DNA Polymerase Mu with Templating Adenine and Mg-8oxodGMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
6IPK	Binary Complex of Human DNA Polymerase Mu with Mn8oxodGTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, ... 著者 Chang, Y.K, Wu, W.J, Tsai, M.D. 登録日 2018-11-03 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
5AIM	Crystal structure of T138 central eWH domain 分子名称: GLYCEROL, TRANSCRIPTION FACTOR TAU 138 KDA SUBUNIT 著者 Male, G, Glatt, S, Mueller, C.W. 登録日 2015-02-16 公開日 2015-06-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.401 Å) 主引用文献 Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly. Nat Commun, 6, 2015
8F5M	Crystal structure of P74 gp62 分子名称: Envelope glycoprotein gp62, MAGNESIUM ION 著者 Bae, B, Nair, S.K. 登録日 2022-11-14 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail. Nat Commun, 15, 2024
2XYM	HCV-JFH1 NS5B T385A mutant 分子名称: PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE 著者 Simister, P.C, Caillet-Saguy, C, Bressanelli, S. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.774 Å) 主引用文献 A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes. J.Virol., 85, 2011
3SKH	I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles 分子名称: 1-benzyl-5-chloro-3-(2-fluorophenyl)-1H-indole-2-carboxylic acid, HCV NS5B RNA_DEPENDENT RNA POLYMERASE 著者 Lesburg, C.A, Anilkumar, G.N. 登録日 2011-06-22 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles. Bioorg.Med.Chem.Lett., 21, 2011
7ELB	Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) 分子名称: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... 著者 Peng, R, Xu, X, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
7ELC	Structure of monomeric complex of MACV L bound to Z and 3'-vRNA 分子名称: 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... 著者 Xu, X, Peng, R, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
3TYQ	SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase 分子名称: 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Lesburg, C.A, Chen, K.X. 登録日 2011-09-26 公開日 2012-02-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors. J.Med.Chem., 55, 2012
4EP7	Functional implications from the Cid1 poly(U) polymerase crystal structure 分子名称: MAGNESIUM ION, Poly(A) RNA polymerase protein cid1, URIDINE 5'-TRIPHOSPHATE 著者 Munoz-Tello, P, Gabus, C, Thore, S. 登録日 2012-04-17 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2805 Å) 主引用文献 Functional implications from the cid1 poly(u) polymerase crystal structure. Structure, 20, 2012
7OE7	Apo-structure of Lassa virus L protein (well-resolved alpha ribbon) [APO-RIBBON] 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-01 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7OE3	Apo-structure of Lassa virus L protein (well-resolved endonuclease) [APO-ENDO] 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-01 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7OJK	Lassa virus L protein bound to the distal promoter duplex [DISTAL-PROMOTER] 分子名称: 3' RNA, 5' RNA, RNA-directed RNA polymerase L, ... 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-16 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7OJL	Lassa virus L protein in a pre-initiation conformation [PREINITIATION] 分子名称: 3' RNA, 5' RNA, MANGANESE (II) ION, ... 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-16 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7OJN	Lassa virus L protein in an elongation conformation [ELONGATION] 分子名称: 3' RNA, 5' RNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... 著者 Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. 登録日 2021-05-16 公開日 2021-12-01 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.92 Å) 主引用文献 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021

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