1Z4U

hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585

Summary for 1Z4U

• Entry DOI: 10.2210/pdb1z4u/pdb
• Related: 1YVF
• Descriptor: HCV NS5B POLYMERASE, CHLORIDE ION, PHOSPHATE ION, ... (6 entities in total)
• Functional Keywords: ns5b, polymerase, hcv, fingers, palm, thumb, transferase
• Biological source: Hepatitis C virus
• Total number of polymer chains: 1
• Total formula weight: 65287.17

Authors

Pfefferkorn, J.A.,Greene, M.,Nugent, R.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R. (deposition date: 2005-03-16, release date: 2005-06-07, Last modification date: 2024-04-03)

Primary citation

Pfefferkorn, J.A.,Nugent, R.,Gross, R.J.,Greene, M.,Mitchell, M.A.,Reding, M.T.,Funk, L.A.,Anderson, R.,Wells, P.A.,Shelly, J.A.,Anstadt, R.,Finzel, B.C.,Harris, M.S.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J.
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid
Bioorg.Med.Chem.Lett., 15:2812-2818, 2005

PubMed Abstract: A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.

PubMed: 15911260
DOI: 10.1016/j.bmcl.2005.03.106

Experimental method

X-RAY DIFFRACTION (2.8 Å)