1Z4U

hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585

Summary for 1Z4U

Related1YVF
DescriptorHCV NS5B POLYMERASE, CHLORIDE ION, PHOSPHATE ION, ... (6 entities in total)
Functional Keywordsns5b, polymerase, hcv, fingers, palm, thumb, transferase
Biological sourceHepatitis C virus
Total number of polymer chains1
Total molecular weight65287.17
Authors
Pfefferkorn, J.A.,Greene, M.,Nugent, R.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R. (deposition date: 2005-03-16, release date: 2005-06-07, Last modification date: 2017-10-11)
Primary citation
Pfefferkorn, J.A.,Nugent, R.,Gross, R.J.,Greene, M.,Mitchell, M.A.,Reding, M.T.,Funk, L.A.,Anderson, R.,Wells, P.A.,Shelly, J.A.,Anstadt, R.,Finzel, B.C.,Harris, M.S.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J.
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid
Bioorg.Med.Chem.Lett., 15:2812-2818, 2005
PubMed: 15911260 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2005.03.106
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266231.6%2.9%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution