1YVF

Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

Summary for 1YVF

• Entry DOI: 10.2210/pdb1yvf/pdb
• Descriptor: HCV NS5B POLYMERASE, PHOSPHATE ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: ns5b, polymerase, hcv, fingers, palm, thumb, transferase
• Biological source: Hepatitis C virus
• Total number of polymer chains: 1
• Total formula weight: 65319.13

Authors

Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J. (deposition date: 2005-02-15, release date: 2005-04-19, Last modification date: 2024-02-14)

Primary citation

Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J.
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid.
Bioorg.Med.Chem.Lett., 15:2481-2486, 2005

PubMed Abstract: A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern heterobiaryl region of the template led to the synthesis of several potent and orally bioavailable lead compounds. X-ray crystallography studies were also performed to understand the interaction of these inhibitors with HCV NS5B polymerase.

PubMed: 15863301
DOI: 10.1016/j.bmcl.2005.03.066

Experimental method

X-RAY DIFFRACTION (2.5 Å)