Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

Summary for 1YVF

DescriptorHCV NS5B POLYMERASE, PHOSPHATE ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsns5b, polymerase, hcv, fingers, palm, thumb, transferase
Biological sourceHepatitis C virus
Total number of polymer chains1
Total molecular weight65319.13
Primary citation
Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J.
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid.
Bioorg.Med.Chem.Lett., 15:2481-2486, 2005
PubMed: 15863301 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2005.03.066
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.304202.5%1.7%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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