PDB: 41522 件ウェブページステータス検索Chemie searchBIRD

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4EHN	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
6TLC	Unphosphorylated human STAT3 in complex with MS3-6 monobody 分子名称: Monobody, Signal transducer and activator of transcription 3 著者 La Sala, G, Lau, K, Reynaud, A, Pojer, F, Hantschel, O. 登録日 2019-12-02 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat Commun, 11, 2020
6TTX	Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051) 分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-(piperidin-4-ylmethyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. 登録日 2019-12-30 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. Chemmedchem, 15, 2020
4X4K	Structure of laccase from Botrytis aclada with full copper content 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Laccase, ... 著者 Osipov, E.M, Polyakov, K.M, Tikhonova, T.V, Kittl, R, Shleev, S.V, Ludwig, R, Popov, V.O. 登録日 2014-12-03 公開日 2015-12-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Incorporation of copper ions into crystals of T2 copper-depleted laccase from Botrytis aclada. Acta Crystallogr.,Sect.F, 71, 2015
5FDK	Crystal structure of RecU(D88N) in complex with palindromic DNA duplex 分子名称: Holliday junction resolvase RecU, palindromic DNA 著者 Khavnekar, S, Rafferty, J.B, Kale, A. 登録日 2015-12-16 公開日 2016-12-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.208 Å) 主引用文献 Structural insights into dynamics of RecU-HJ complex formation elucidates key role of NTR and stalk region toward formation of reactive state. Nucleic Acids Res., 45, 2017
5FFL	Crystal structure of mouse CD300lf at 1.6 Angstroms resolution. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CD300 antigen-like family member F, ... 著者 Nelson, C.A, Fremont, D.H. 登録日 2015-12-18 公開日 2016-08-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Discovery of a proteinaceous cellular receptor for a norovirus. Science, 353, 2016
3OSS	The crystal structure of enterotoxigenic Escherichia coli GspC-GspD complex from the type II secretion system 分子名称: CALCIUM ION, CHLORIDE ION, TYPE 2 SECRETION SYSTEM, ... 著者 Korotkov, K.V, Pruneda, J, Hol, W.G.J. 登録日 2010-09-09 公開日 2011-08-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. Plos Pathog., 7, 2011
6TTP	Crystal structure of the human METTL3-METTL14 complex bound to Compound 1/Adenosine (DHU_M3M_023) 分子名称: ACETATE ION, ADENOSINE, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. 登録日 2019-12-30 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. Chemmedchem, 15, 2020
7VKE	Crystal structure of human CD38 ECD in complex with UniDab(TM) F11A 分子名称: 1,2-ETHANEDIOL, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, CHLORIDE ION, ... 著者 Schooten, W.V, Schellenberger, U, Ugamraj, H.S, Manicka, S, Bijpuria, S, Gondu, R.K. 登録日 2021-09-29 公開日 2022-08-03 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity. Mabs, 14, 2022
5NR7	Mtb TMK crystal structure in complex with compound 43 分子名称: 1-[1-[[4-(3-chloranylphenoxy)quinolin-2-yl]methyl]piperidin-4-yl]-5-methyl-pyrimidine-2,4-dione, CHLORIDE ION, Thymidylate kinase 著者 Merceron, R, Song, L, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S. 登録日 2017-04-22 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J. Med. Chem., 61, 2018
5FB0	Crystal Structure of a PHD finger bound to histone H3 T3ph peptide 分子名称: Nuclear autoantigen Sp-100, Peptide from Histone H3, ZINC ION 著者 Li, H, Zhang, X. 登録日 2015-12-13 公開日 2016-05-04 最終更新日 2016-06-22 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C J.Biol.Chem., 291, 2016
6TU1	Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ASI_M3M_091) 分子名称: (2~{R},3~{R},4~{R},5~{R})-2-[(6-aminopurin-9-yl)methyl]-5-azanyl-oxane-3,4-diol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. 登録日 2019-12-31 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. Chemmedchem, 15, 2020
6T0E	The glucuronoyl esterase OtCE15A S267A variant from Opitutus terrae in complex with benzyl D-glucuronoate and D-glucuronate 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Mazurkewich, S, Navarro Poulsen, J.C, Larsbrink, J, Lo Leggio, L. 登録日 2019-10-03 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structural and biochemical studies of the glucuronoyl esteraseOtCE15A illuminate its interaction with lignocellulosic components. J.Biol.Chem., 294, 2019
1GHT	SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF GAMMA DELTA RESOLVASE 分子名称: TRANSPOSON GAMMA-DELTA RESOLVASE 著者 Pan, B, Mullen, G.P. 登録日 2001-01-11 公開日 2001-08-01 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the catalytic domain of gammadelta resolvase. Implications for the mechanism of catalysis. J.Mol.Biol., 310, 2001
4EHF	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.655 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
6SKK	Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,8) 分子名称: capsid protein 著者 Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. 登録日 2019-08-15 公開日 2020-08-26 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Nat.Struct.Mol.Biol., 27, 2020
2VEQ	Insights into kinetochore-DNA interactions from the structure of Cep3p 分子名称: BETA-MERCAPTOETHANOL, CACODYLATE ION, CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B 著者 Purvis, A, Singleton, M.R. 登録日 2007-10-26 公開日 2007-12-25 最終更新日 2017-07-12 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Insights Into Kinetochore-DNA Interactions from the Structure of Cep3Delta Embo Rep., 9, 2008
6SPM	Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 4-(trifluoromethyl)benzoic acid 分子名称: 4-(trifluoromethyl)benzoic acid, DIMETHYL SULFOXIDE, METHANOL, ... 著者 Oebbeke, M, Siefker, C, Heine, A, Klebe, G. 登録日 2019-09-02 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
6SPU	Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with 3-aminobenzoic acid 分子名称: 3-AMINOBENZOIC ACID, DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha 著者 Oebbeke, M, Siefker, C, Heine, A, Klebe, G. 登録日 2019-09-02 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
2V1S	CRYSTAL STRUCTURE OF RAT TOM20-ALDH PRESEQUENCE COMPLEX 分子名称: ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG 著者 Obita, T, Igura, M, Ose, T, Endo, T, Maenaka, K, Kohda, D. 登録日 2007-05-29 公開日 2007-06-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Tom20 Recognizes Mitochondrial Presequences Through Dynamic Equilibrium Among Multiple Bound States. Embo J., 26, 2007
4WGJ	Crystal Structure of BepC protein (VirB-translocated Bartonella effector protein) with bound AMPPNP from Bartonella tribocorum 分子名称: 1,2-ETHANEDIOL, BepC protein, GLYCINE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2014-09-18 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module. Microorganisms, 9, 2021
4M55	Crystal structure of Human UDP-xylose synthase R236H substitution 分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYROPHOSPHATE 2-, SULFATE ION, ... 著者 Walsh Jr, R.M, Polizzi, S.J, Wood, Z.A. 登録日 2013-08-08 公開日 2013-08-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation. Biochemistry, 54, 2015
4WQT	Thermus thermophilus RNA polymerase complexed with an RNA cleavage stimulating factor (a GreA/Gfh1 chimeric protein) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murayama, Y, Sekine, S, Yokoyama, S. 登録日 2014-10-22 公開日 2015-02-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions. Mol.Cell, 57, 2015
7KDT	Human Tom70 in complex with SARS CoV2 Orf9b 分子名称: Mitochondrial import receptor subunit TOM70, ORF9b protein 著者 QCRG Structural Biology Consortium 登録日 2020-10-09 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370, 2020
2VY6	Two domains from the C-terminal region of influenza A virus polymerase PB2 subunit 分子名称: POLYMERASE BASIC PROTEIN 2 著者 Tarendeau, F, Crepin, T, Guilligay, D, Ruigrok, R, Cusack, S, Hart, D. 登録日 2008-07-18 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase Pb2 Subunit Plos Pathog., 4, 2008

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