7ALW
 
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4H6A
 | | Crystal Structure of the Allene Oxide Cyclase 2 from Physcomitrella patens | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Allene oxide cyclase, ... | | 著者 | Neumann, P, Ficner, R. | | 登録日 | 2012-09-19 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity.
Plant Physiol., 160, 2012
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7AWE
 | | HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid | | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | | 著者 | Musil, D, Klein, M. | | 登録日 | 2020-11-06 | | 公開日 | 2021-06-09 | | 最終更新日 | 2021-08-11 | | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | | 主引用文献 | M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i) Delivering Efficacy in Multiple Myeloma Models.
Mol.Cancer Ther., 20, 2021
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7ASL
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5MS4
 | | Kallikrein-related peptidase 8 leupeptin inhibitor complex | | 分子名称: | CALCIUM ION, Kallikrein-8, LEUPEPTIN, ... | | 著者 | Debela, M, Magdolen, V, Skala, W, Bode, W, Brandstetter, H, Goettig, P. | | 登録日 | 2016-12-30 | | 公開日 | 2018-01-17 | | 最終更新日 | 2019-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
Sci Rep, 8, 2018
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5MNV
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7ASH
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4PB6
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5OOM
 | | Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA | | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | | 著者 | Brown, A, Rathore, S, Kimanius, D, Aibara, S, Bai, X.C, Rorbach, J, Amunts, A, Ramakrishnan, V. | | 登録日 | 2017-08-08 | | 公開日 | 2017-09-13 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structures of the human mitochondrial ribosome in native states of assembly.
Nat. Struct. Mol. Biol., 24, 2017
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4PDS
 | | Crystal structure of Rad53 kinase domain and SCD2 in complex with AMPPNP | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase RAD53 | | 著者 | Ho, C.S, Wybenga-Groot, L.E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2014-04-21 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.
Cell Signal., 26, 2014
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3JBN
 | | Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... | | 著者 | Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. | | 登録日 | 2015-09-16 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
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7AFI
 | | Bacterial 30S ribosomal subunit assembly complex state C (body domain) | | 分子名称: | 16SrRNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Kaminishi, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S. | | 登録日 | 2020-09-19 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Sci Adv, 7, 2021
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1YG8
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4HGF
 | | Crystal structure of P450 BM3 5F5K heme domain variant complexed with styrene | | 分子名称: | Bifunctional P-450/NADPH-P450 reductase, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Shehzad, A, Panneerselvam, S, Bocola, M, Mueller-Dieckmann, J, Wilmanns, M, Schwaneberg, U. | | 登録日 | 2012-10-08 | | 公開日 | 2013-05-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation.
Chem.Commun.(Camb.), 49, 2013
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3K8T
 | | Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound | | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... | | 著者 | Sun, D, Xu, H, Dealwis, C, Lee, R.E. | | 登録日 | 2009-10-14 | | 公開日 | 2010-03-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors
Chemmedchem, 4, 2009
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4QV7
 | | yCP beta5-A50V mutant | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | | 登録日 | 2014-07-14 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23, 2015
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3JR3
 | | Sir2 bound to acetylated peptide | | 分子名称: | Acetylated Peptide, NAD-dependent deacetylase, ZINC ION | | 著者 | Hawse, W.F, Wolberger, C. | | 登録日 | 2009-09-08 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-based mechanism of ADP-ribosylation by sirtuins.
J.Biol.Chem., 284, 2009
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4QW0
 | | yCP beta5-A49T-A50V-double mutant in complex with bortezomib | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | | 登録日 | 2014-07-16 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23, 2015
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4QV5
 | | yCP beta5-M45I mutant | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | | 登録日 | 2014-07-14 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23, 2015
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1YDW
 | | X-RAY STRUCTURE OF GENE PRODUCT FROM ARABIDOPSIS THALIANA AT4G09670 | | 分子名称: | AX110P-like protein | | 著者 | Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2004-12-26 | | 公開日 | 2005-01-11 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.488 Å) | | 主引用文献 | X-RAY STRUCTURE OF GENE PRODUCT FROM ARABIDOPSIS THALIANA AT4G09670
To be published
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4QWG
 | | yCP beta5-A49V mutant in complex with carfilzomib | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | | 登録日 | 2014-07-16 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23, 2015
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4QZ5
 | | yCP beta5-A49T-mutant in complex with ONX 0914 | | 分子名称: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Huber, E.M, Heinemeyer, W, Groll, M. | | 登録日 | 2014-07-27 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23, 2015
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3J3W
 | | Atomic model of the immature 50S subunit from Bacillus subtilis (state II-a) | | 分子名称: | 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | | 著者 | Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N. | | 登録日 | 2013-04-28 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (10.7 Å) | | 主引用文献 | Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
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3J80
 | | CryoEM structure of 40S-eIF1-eIF1A preinitiation complex | | 分子名称: | 18S rRNA, MAGNESIUM ION, RACK1, ... | | 著者 | Hussain, T, Llacer, J.L, Fernandez, I.S, Savva, C.G, Ramakrishnan, V. | | 登録日 | 2014-08-28 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | Structural changes enable start codon recognition by the eukaryotic translation initiation complex.
Cell(Cambridge,Mass.), 159, 2014
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7B7S
 | | CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368 | | 分子名称: | 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, Cyclin-A2, Cyclin-dependent kinase 2, ... | | 著者 | Djukic, S, Skerlova, J, Rezacova, P. | | 登録日 | 2020-12-11 | | 公開日 | 2021-08-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
J.Med.Chem., 64, 2021
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