3K8T

Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound

Summary for 3K8T

Entry DOI	10.2210/pdb3k8t/pdb
Descriptor	Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	eukaryotic ribonucleotide reductase, nucleotide analogs, allosteric enzyme atp-binding, dna replication, nucleotide-binding oxidoreductase, phosphoprotein, allosteric enzyme, atp-binding, nucleotide-binding, oxidoreductase
Biological source	Saccharomyces cerevisiae (yeast)
Cellular location	Cytoplasm: P21524
Total number of polymer chains	1
Total formula weight	100751.82
Authors	Sun, D.,Xu, H.,Dealwis, C.,Lee, R.E. (deposition date: 2009-10-14, release date: 2010-03-02, Last modification date: 2023-09-06)
Primary citation	Sun, D.,Xu, H.,Wijerathna, S.R.,Dealwis, C.,Lee, R.E. Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4:1649-1656, 2009 Cited by PubMed: 19681093 DOI: 10.1002/cmdc.200900236 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation