7AWE

HUMAN IMMUNOPROTEASOME 20S PARTICLE IN COMPLEX WITH [(1R)-2-(1-benzofuran-3-yl)-1-{[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid

Summary for 7AWE

• Entry DOI: 10.2210/pdb7awe/pdb
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (18 entities in total)
• Functional Keywords: multicatalytic proteinase, 20s proteasome, protease, hydrolase, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 28
• Total formula weight: 695590.05

Authors

Musil, D.,Klein, M. (deposition date: 2020-11-06, release date: 2021-06-09, Last modification date: 2021-08-11)

• Primary citation: Sanderson, M.P.,Friese-Hamim, M.,Walter-Bausch, G.,Busch, M.,Gaus, S.,Musil, D.,Rohdich, F.,Zanelli, U.,Downey-Kopyscinski, S.L.,Mitsiades, C.S.,Schadt, O.,Klein, M.,Esdar, C.; M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 ( beta 5i) Delivering Efficacy in Multiple Myeloma Models.; Mol.Cancer Ther., 20:1378-1387, 2021; PubMed: 34045234; DOI: 10.1158/1535-7163.MCT-21-0005

Experimental method

X-RAY DIFFRACTION (2.288 Å)