5FSA
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![BU of 5fsa by Molmil](/molmil-images/mine/5fsa) | Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole | 分子名称: | CYP51 VARIANT1, POSACONAZOLE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Hargrove, T.Y, Wawrzak, Z, Friggeri, L, Lepesheva, G.I. | 登録日 | 2016-01-02 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J. Biol. Chem., 292, 2017
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4H3G
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![BU of 4h3g by Molmil](/molmil-images/mine/4h3g) | Structure of BACE Bound to 2-((7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)nicotinonitrile | 分子名称: | 2-{(2E,4aR,7aR)-7a-[4-(3-cyanophenyl)thiophen-2-yl]-2-imino-3-methyl-4-oxooctahydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl}pyridine-3-carbonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | 著者 | Strickland, C, Mandal, M. | 登録日 | 2012-09-13 | 公開日 | 2012-11-07 | 最終更新日 | 2012-11-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation. J.Med.Chem., 55, 2012
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7W5B
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![BU of 7w5b by Molmil](/molmil-images/mine/7w5b) | The cryo-EM structure of human C* complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-06-22 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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5FN4
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![BU of 5fn4 by Molmil](/molmil-images/mine/5fn4) | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | 登録日 | 2015-11-10 | 公開日 | 2015-12-16 | 最終更新日 | 2019-09-11 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase. Elife, 4, 2015
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6SNI
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![BU of 6sni by Molmil](/molmil-images/mine/6sni) | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | 分子名称: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | 登録日 | 2019-08-24 | 公開日 | 2020-03-11 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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5FO8
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![BU of 5fo8 by Molmil](/molmil-images/mine/5fo8) | Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3, ... | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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7W5A
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![BU of 7w5a by Molmil](/molmil-images/mine/7w5a) | The cryo-EM structure of human pre-C*-II complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-06-22 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W59
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![BU of 7w59 by Molmil](/molmil-images/mine/7w59) | The cryo-EM structure of human pre-C*-I complex | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | 著者 | Zhan, X, Lu, Y, Shi, Y. | 登録日 | 2021-11-29 | 公開日 | 2022-06-22 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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5FZ5
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![BU of 5fz5 by Molmil](/molmil-images/mine/5fz5) | Transcription initiation complex structures elucidate DNA opening (CC) | 分子名称: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | 著者 | Plaschka, C, Hantsche, M, Dienemann, C, Burzinski, C, Plitzko, J, Cramer, P. | 登録日 | 2016-03-10 | 公開日 | 2016-05-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (8.8 Å) | 主引用文献 | Transcription Initiation Complex Structures Elucidate DNA Opening Nature, 533, 2016
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3CYR
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![BU of 3cyr by Molmil](/molmil-images/mine/3cyr) | CYTOCHROME C3 FROM DESULFOVIBRIO DESULFURICANS ATCC 27774P | 分子名称: | CYTOCHROME C3, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Simoes, P, Matias, P.M, Morais, J, Wilson, K, Dauter, Z, Carrondo, M.A. | 登録日 | 1997-07-24 | 公開日 | 1998-01-28 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Refinement of the Three-Dimensional Structures of Cytochrome C3 from Desulfovibrio Vulgaris Hildenborough at 1.67 Angstroms Resolution and from Desulfovibrio Desulfuricans Atcc 27774 at 1.6 Angstroms Resolution Inorg.Chim.Acta., 273, 1998
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4HA5
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![BU of 4ha5 by Molmil](/molmil-images/mine/4ha5) | Structure of BACE Bound to (S)-3-(5-(2-imino-1,4-dimethyl-6-oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile | 分子名称: | 3-{5-[(2E,4S)-2-imino-1,4-dimethyl-6-oxohexahydropyrimidin-4-yl]thiophen-3-yl}benzonitrile, Beta-secretase 1, L(+)-TARTARIC ACID | 著者 | Strickland, C, Mandal, M. | 登録日 | 2012-09-25 | 公開日 | 2012-10-17 | 最終更新日 | 2012-11-21 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation. J.Med.Chem., 55, 2012
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8JAH
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![BU of 8jah by Molmil](/molmil-images/mine/8jah) | |
2INZ
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![BU of 2inz by Molmil](/molmil-images/mine/2inz) | Crystal Structure of Aldose Reductase complexed with 2-Hydroxyphenylacetic Acid | 分子名称: | (2-HYDROXYPHENYL)ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Harrison, D.H.T, Pape, E, Carlson, E, Brownlee, J.M. | 登録日 | 2006-10-09 | 公開日 | 2006-11-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg.Chem., 34, 2006
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2J10
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![BU of 2j10 by Molmil](/molmil-images/mine/2j10) | p53 tetramerization domain mutant T329F Q331K | 分子名称: | CELLULAR TUMOR ANTIGEN P53 | 著者 | Carbajo, R.J, Mora, P, Sanchez del Pino, M.M, Perez-Paya, E, Pineda-Lucena, A. | 登録日 | 2006-08-08 | 公開日 | 2007-08-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach. Proteins, 71, 2008
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2YC2
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![BU of 2yc2 by Molmil](/molmil-images/mine/2yc2) | |
6SNH
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![BU of 6snh by Molmil](/molmil-images/mine/6snh) | Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc | 分子名称: | 6AG9 Fab heavy chain, 6AG9 Fab light chain, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, ... | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | 登録日 | 2019-08-24 | 公開日 | 2020-03-11 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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6YMQ
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![BU of 6ymq by Molmil](/molmil-images/mine/6ymq) | TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Single-chain variable 4, ... | 著者 | Szykowska, A, Preger, C, Scacioc, A, Mukhopadhyay, S.M.M, McKinley, G, Graslund, S, Wigren, E, Persson, H, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Di Daniel, E, Davis, J.B, Burgess-Brown, N, Bullock, A. | 登録日 | 2020-04-09 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure, 29, 2021
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5GHJ
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![BU of 5ghj by Molmil](/molmil-images/mine/5ghj) | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHP
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![BU of 5ghp by Molmil](/molmil-images/mine/5ghp) | Crystal structure of human MTH1(G2K/D120A mutant) in complex with 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.192 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GG5
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![BU of 5gg5 by Molmil](/molmil-images/mine/5gg5) | Crystal structure of Mycobacterium smegmatis MutT1 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Hydrolase, ... | 著者 | Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. | 登録日 | 2016-06-15 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
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5GG8
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![BU of 5gg8 by Molmil](/molmil-images/mine/5gg8) | Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-dGTP, 8-oxo-dGMP and pyrophosphate (II) | 分子名称: | 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Hydrolase, ... | 著者 | Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. | 登録日 | 2016-06-15 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
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5GG9
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![BU of 5gg9 by Molmil](/molmil-images/mine/5gg9) | Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-GTP, 8-oxo-GMP and pyrophosphate | 分子名称: | 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, Hydrolase, NUDIX family protein, ... | 著者 | Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. | 登録日 | 2016-06-15 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
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6YB1
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![BU of 6yb1 by Molmil](/molmil-images/mine/6yb1) | Crystal structure of an antiparallel octameric transmembrane coiled coil K2-CCTM-VbIc | 分子名称: | GLYCINE, K2-CCTM-VbIc, NONAETHYLENE GLYCOL | 著者 | Kratochvil, H.T, Liu, L, Scott, A.J, Woolfson, D.N, DeGrado, W.F. | 登録日 | 2020-03-15 | 公開日 | 2021-04-07 | 最終更新日 | 2021-07-14 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Constructing ion channels from water-soluble alpha-helical barrels. Nat.Chem., 13, 2021
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2BJ6
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![BU of 2bj6 by Molmil](/molmil-images/mine/2bj6) | Crystal Structure of a decameric HNA-RNA hybrid | 分子名称: | 5'-R(*GP*GP*CP*AP*UP*UP*AP*CP*GP*GP)-3', SULFATE ION, SYNTHETIC HNA | 著者 | Maier, T, Przylas, I, Straeter, N, Herdewijn, P, Saenger, W. | 登録日 | 2005-01-30 | 公開日 | 2005-03-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Reinforced Hna Backbone Hydration in the Crystal Structure of a Decameric Hna/RNA Hybrid J.Am.Chem.Soc., 127, 2005
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5F8A
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![BU of 5f8a by Molmil](/molmil-images/mine/5f8a) | Crystal structure of the ternary EcoRV-DNA-Lu complex with uncleaved DNA substrate. Lanthanide binding to EcoRV-DNA complex inhibits cleavage. | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*T)-3'), LUTETIUM (III) ION, ... | 著者 | Sangani, S.S, Kehr, A.D, Sinha, K, Rule, G.S, Jen-Jacobson, L. | 登録日 | 2015-12-09 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Metal Ion Binding at the Catalytic Site Induces Widely Distributed Changes in a Sequence Specific Protein-DNA Complex. Biochemistry, 55, 2016
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