PDB: 37044 件ウェブページステータス検索Chemie searchBIRD

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4K44	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Hajicek, N, Sondek, J. 登録日 2013-04-11 公開日 2013-06-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
7XX3	Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) 分子名称: (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Padmanabhan, B, Unni, S. 登録日 2022-05-28 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phialomustin-B a fungal metabolite isolated from Phialophora mustea modulates Superoxide Dismutase 1 (SOD1) aggregation: Therapeutic potential in Amyotrophic lateral sclerosis (ALS) To Be Published
2WUW	Crystallographic analysis of counter-ion effects on subtilisin enzymatic action in acetonitrile (native data) 分子名称: ACETONITRILE, CALCIUM ION, SODIUM ION, ... 著者 Cianci, M, Tomaszewki, B, Helliwell, J.R, Halling, P.J. 登録日 2009-10-09 公開日 2010-12-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Crystallographic Analysis of Counterion Effects on Subtilisin Enzymatic Action in Acetonitrile. J.Am.Chem.Soc., 132, 2010
4EP6	Crystal structure of the XplA heme domain in complex with imidazole and PEG 分子名称: Cytochrome P450-like protein XplA, IMIDAZOLE, PENTAETHYLENE GLYCOL, ... 著者 Bui, S.H, McLean, K.J, Cheesman, M.R, Bradley, J.M, Rigby, S.E.J, Leys, D, Munro, A.W. 登録日 2012-04-17 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA. J.Biol.Chem., 287, 2012
4BVD	Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. 分子名称: 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide, APOLIPOPROTEIN(A), CHLORIDE ION 著者 Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W. 登録日 2013-06-25 公開日 2014-07-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published
3PNA	Crystal Structure of cAMP bound (91-244)RIa Subunit of cAMP-dependent Protein Kinase 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit 著者 Kim, C, Taylor, S. 登録日 2010-11-18 公開日 2011-02-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.503 Å) 主引用文献 Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design. Mol Cell Proteomics, 10, 2011
2WY4	Structure of bacterial globin from Campylobacter jejuni at 1.35 A resolution 分子名称: CYANIDE ION, PROTOPORPHYRIN IX CONTAINING FE, SINGLE DOMAIN HAEMOGLOBIN 著者 Barynin, V.V, Sedelnikova, S.E, Shepherd, M, Wu, G, Poole, R.K, Rice, D.W. 登録日 2009-11-11 公開日 2010-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The Single-Domain Globin from the Pathogenic Bacterium Campylobacter Jejuni: Novel D-Helix Conformation, Proximal Hydrogen Bonding that Influences Ligand Binding, and Peroxidase-Like Redox Properties. J.Biol.Chem., 285, 2010
4K60	Crystal Structure of Human Chymase in Complex with Fragment 6-bromo-1,3-dihydro-2H-indol-2-one 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-bromo-1,3-dihydro-2H-indol-2-one, Chymase, ... 著者 Collins, B.K, Padyana, A.K. 登録日 2013-04-15 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56, 2013
4K2Y	Crystal Structure of Human Chymase in Complex with Fragment Inhibitor 6-chloro-1,3-dihydro-2H-indol-2-one 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-chloro-1,3-dihydro-2H-indol-2-one, Chymase, ... 著者 Collins, B.K, Padyana, A.K. 登録日 2013-04-09 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56, 2013
2WWP	Crystal structure of the human lipocalin-type prostaglandin D synthase 分子名称: CHLORIDE ION, PROSTAGLANDIN-H2 D-ISOMERASE, THIOCYANATE ION 著者 Roos, A.K, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotyenova, T, Kotzch, A, Kraulis, P, Markova, N, Moche, M, Nielsen, T.K, Nyman, T, Persson, C, Schuler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC) 登録日 2009-10-26 公開日 2010-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and Dynamic Insights Into Substrate Binding and Catalysis of Human Lipocalin Prostaglandin D Synthase. J.Lipid Res., 54, 2013
4BVN	Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, ... 著者 Miller, J, Nehme, R, Warne, T, Edwards, P.C, Leslie, A.G.W, Schertler, G, Tate, C.G. 登録日 2013-06-26 公開日 2014-04-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The 2.1 A Resolution Structure of Cyanopindolol-Bound Beta1- Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor. Plos One, 9, 2014
4EGP	The X-ray crystal structure of CYP199A4 in complex with 2-naphthoic acid 分子名称: CHLORIDE ION, Cytochrome P450, GLYCEROL, ... 著者 Zhou, W, Bell, S.G, Yang, W, Zhou, R.M, Tan, A.B.H, Wong, L.-L. 登録日 2012-03-31 公開日 2013-02-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering Chemistry, 18, 2012
4K4R	TL-3 inhibited Trp6Ala HIV Protease with 1-bromo-2-napthoic acid bound in exosite 分子名称: 1-bromonaphthalene-2-carboxylic acid, BROMIDE ION, DIMETHYL SULFOXIDE, ... 著者 Tiefenbrunn, T, Stout, C.D. 登録日 2013-04-12 公開日 2013-09-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease. Chem.Biol.Drug Des., 83, 2014
4EX1	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-04-29 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.657 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
3PPT	REP1-NXSQ fatty acid transporter 分子名称: PALMITOLEIC ACID, ReP1-NCXSQ 著者 Berberian, G, Bollo, M, Howard, E, Cousido-Siah, A, Mitschler, A, Ayoub, D, Sanglier-Cianferani, S, Van Dorsselaer, A, DiPolo, R, Beauge, L, Petrova, T, Schulze-Briese, C, Wang, M, Podjarny, A. 登録日 2010-11-25 公開日 2011-12-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger. Acta Crystallogr.,Sect.D, 68, 2012
3PI4	Crystallographic Structure of HbII-oxy from Lucina pectinata at pH 4.0 分子名称: Hemoglobin II, PROTOPORPHYRIN IX CONTAINING FE 著者 Gavira, J.A, Nieves-Marrero, C.A, Ruiz-Martinez, C.R, Estremera-Andujar, R.A, Lopez-Garriga, J, Garcia-Ruiz, J.M. 登録日 2010-11-05 公開日 2011-11-09 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 pH-dependence crystallographic studies of the oxygen carrier hemoglobin II from Lucina pectinata To be Published
4EXZ	Crystal Structure of the Q108K:K40L Mutant of Cellular Retinol Binding Protein Type II in Complex with All-trans-Retinal at 1.7 Angstrom Resolution 分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2 著者 Nossoni, Z, Geiger, J.H. 登録日 2012-05-01 公開日 2012-12-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.608 Å) 主引用文献 Tuning the electronic absorption of protein-embedded all-trans-retinal. Science, 338, 2012
4EY9	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-05-01 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
3PIT	Crystal structure of M-RasD41E in complex with GppNHp (type 2) 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras 著者 Muraoka, S, Matsumoto, K, Shima, F, Hu, L, Ijiri, Y, Hirai, R, Liao, J, Kataoka, T. 登録日 2010-11-08 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of M-RasD41E in complex with GppNHp (type 2) To be Published
4EYD	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-05-01 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4C3W	Vanadium(IV)-Picolinate Complexed with Lysozyme 分子名称: ACETATE ION, CHLORIDE ION, LYSOZYME C, ... 著者 Santos, M.F.A, Correia, I, Oliveira, A.R, Garribba, E, Pessoa, J.C, Romao, M.J, Santos-Silva, T. 登録日 2013-08-28 公開日 2014-07-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V(Iv) Lysozyme Adduct Eur.J.Inorg.Chem., 21, 2014
4C49	Reactive loop cleaved human CBG in complex with cortisol 分子名称: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, CORTICOSTEROID-BINDING GLOBULIN 著者 Chan, W.L, Zhou, A, Read, R.J. 登録日 2013-09-02 公開日 2014-10-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Role of Sa-Hd Loop Movement in Cortisol Release Mechanism of Cbg To be Published
4BV7	Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. 分子名称: 3-(4-piperidyl)propanoic acid, ACETATE ION, APOLIPOPROTEIN(A) 著者 Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W. 登録日 2013-06-25 公開日 2014-07-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published
4K9V	Complex of CYP3A4 with a desoxyritonavir analog 分子名称: 1,3-thiazol-5-ylmethyl [(3S,6S)-6-{[N-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-seryl]amino}octan-3-yl]carbamate, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I.F, Poulos, T.L. 登録日 2013-04-21 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues. Biochemistry, 52, 2013
1HJ9	Atomic resolution structures of trypsin provide insight into structural radiation damage 分子名称: ANILINE, BETA-TRYPSIN, CALCIUM ION, ... 著者 Leiros, H.-K.S, McSweeney, S.M, Smalas, A.O. 登録日 2001-01-10 公開日 2002-01-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (0.95 Å) 主引用文献 Atomic Resolution Structure of Trypsin Provide Insight Into Structural Radiation Damage Acta Crystallogr.,Sect.D, 57, 2001

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