8T4O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t4o by Molmil](/molmil-images/mine/8t4o) | Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347 inhibitor with no glutamate | 分子名称: | 4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoic acid, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], Serine hydroxymethyltransferase, ... | 著者 | Katinas, J.M, Dann III, C.E. | 登録日 | 2023-06-09 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry, 2024
|
|
8T4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t4m by Molmil](/molmil-images/mine/8t4m) | Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | 登録日 | 2023-06-09 | 公開日 | 2024-06-12 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
|
|
8T4C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t4c by Molmil](/molmil-images/mine/8t4c) | |
8T48
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t48 by Molmil](/molmil-images/mine/8t48) | |
8T42
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t42 by Molmil](/molmil-images/mine/8t42) | Model of TTLL6 MTBH1-2 bound to microtubule | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | 著者 | Mahalingan, K.K, Grotjahn, D, Li, Y, Lander, G.C, Zehr, E.A, Roll-Mecak, A. | 登録日 | 2023-06-08 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for alpha-tubulin-specific and modification state-dependent glutamylation. Nat.Chem.Biol., 2024
|
|
8T3O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t3o by Molmil](/molmil-images/mine/8t3o) | Cryo-EM structure of the TUG-891 bound FFA4-Gq complex | 分子名称: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, ... | 著者 | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | 登録日 | 2023-06-07 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
|
|
8T3L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t3l by Molmil](/molmil-images/mine/8t3l) | TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-06-07 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
|
|
8T36
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t36 by Molmil](/molmil-images/mine/8t36) | Crystal structure of K49 acetylated LC3A in complex with the LIR of TP53INP2/DOR | 分子名称: | 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A chimera | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | 登録日 | 2023-06-07 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.852 Å) | 主引用文献 | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR. Autophagy, 2024
|
|
8T31
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t31 by Molmil](/molmil-images/mine/8t31) | |
8T2O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2o by Molmil](/molmil-images/mine/8t2o) | |
8T2N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2n by Molmil](/molmil-images/mine/8t2n) | Crystal structure of GABARAP in complex with the LIR of NSs3 | 分子名称: | Gamma-aminobutyric acid receptor-associated protein, Non-structural protein S | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | 登録日 | 2023-06-06 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. Plos Pathog., 20, 2024
|
|
8T2M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2m by Molmil](/molmil-images/mine/8t2m) | Crystal structure of GABARAP in complex with the LIR of NSs4 | 分子名称: | Non-structural protein S,Gamma-aminobutyric acid receptor-associated protein chimera | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | 登録日 | 2023-06-06 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. Plos Pathog., 20, 2024
|
|
8T2L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2l by Molmil](/molmil-images/mine/8t2l) | Crystal structure of LC3A in complex with the LIR of NSs4 | 分子名称: | Non-structural protein S,Microtubule-associated proteins 1A/1B light chain 3A chimera | 著者 | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | 登録日 | 2023-06-06 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. Plos Pathog., 20, 2024
|
|
8T2J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2j by Molmil](/molmil-images/mine/8t2j) | |
8T2H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2h by Molmil](/molmil-images/mine/8t2h) | DYRK1A complex with DYR530 | 分子名称: | (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL, ... | 著者 | Montfort, W.R, Basantes, L.E. | 登録日 | 2023-06-06 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue To Be Published
|
|
8T2B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2b by Molmil](/molmil-images/mine/8t2b) | |
8T2A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2a by Molmil](/molmil-images/mine/8t2a) | |
8T29
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t29 by Molmil](/molmil-images/mine/8t29) | |
8T25
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t25 by Molmil](/molmil-images/mine/8t25) | Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at downRBD conformation. | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
|
|
8T23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t23 by Molmil](/molmil-images/mine/8t23) | Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at upRBD conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
|
|
8T22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t22 by Molmil](/molmil-images/mine/8t22) | Cryo-EM structure of mink variant Y453F trimeric spike protein bound to one mink ACE2 receptors at downRBD conformation | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
|
|
8T21
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t21 by Molmil](/molmil-images/mine/8t21) | Cryo-EM structure of mink variant Y453F trimeric spike protein | 分子名称: | Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
|
|
8T20
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t20 by Molmil](/molmil-images/mine/8t20) | Cryo-EM structure of mink variant Y453F trimeric spike protein bound to two mink ACE2 receptors | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | 登録日 | 2023-06-05 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
|
|
8T1R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t1r by Molmil](/molmil-images/mine/8t1r) | Crystal structure of human CPSF73 catalytic segment in complex with compound 2 | 分子名称: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ... | 著者 | Huang, J, Tong, L. | 登録日 | 2023-06-02 | 公開日 | 2023-11-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3. Cell Chem Biol, 31, 2024
|
|
8T1Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t1q by Molmil](/molmil-images/mine/8t1q) | Crystal structure of human CPSF73 catalytic segment in complex with compound 1 | 分子名称: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(4-ethanoylphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ... | 著者 | Huang, J, Tong, L. | 登録日 | 2023-06-02 | 公開日 | 2023-11-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3. Cell Chem Biol, 31, 2024
|
|