8T2L

Crystal structure of LC3A in complex with the LIR of NSs4

Summary for 8T2L

• Entry DOI: 10.2210/pdb8t2l/pdb
• Descriptor: Non-structural protein S,Microtubule-associated proteins 1A/1B light chain 3A chimera (2 entities in total)
• Functional Keywords: rift valley fever virus, autophagy, lc3, gabarap, lir, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 30859.07

Authors

Ali, M.G.H.,Wahba, H.M.,Cyr, N.,Omichinski, J.G. (deposition date: 2023-06-06, release date: 2024-04-03)

• Primary citation: Petraccione, K.,Ali, M.G.H.,Cyr, N.,Wahba, H.M.,Stocker, T.,Akhrymuk, M.,Akhrymuk, I.,Panny, L.,Bracci, N.,Cafaro, R.,Sastre, D.,Silberfarb, A.,O'Maille, P.,Omichinski, J.,Kehn-Hall, K.; An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy.; Plos Pathog., 20:e1012093-e1012093, 2024; PubMed: 38512999; DOI: 10.1371/journal.ppat.1012093

Experimental method

X-RAY DIFFRACTION (2.24 Å)