5ZBQ
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![BU of 5zbq by Molmil](/molmil-images/mine/5zbq) | The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299 | 分子名称: | Neuropeptide Y receptor type 1,T4 Lysozyme, N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino)ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide | 著者 | Yang, Z, Han, S, Zhao, Q, Wu, B. | 登録日 | 2018-02-12 | 公開日 | 2018-04-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of ligand binding modes at the neuropeptide Y Y1receptor Nature, 556, 2018
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5G3L
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![BU of 5g3l by Molmil](/molmil-images/mine/5g3l) | ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER COMPLEXED WITH SIALYLATED SUGAR | 分子名称: | HEAT-LABILE ENTEROTOXIN IIB, B CHAIN, N-acetyl-alpha-neuraminic acid, ... | 著者 | Zalem, D, Benktander, J, Ribeiro, J.P, Varrot, A, Lebens, M, Imberty, A, Teneberg, S. | 登録日 | 2016-04-29 | 公開日 | 2016-09-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Biochemical and Structural Characterization of the Novel Sialic Acid-Binding Site of Escherichia Coli Heat-Labile Enterotoxin Lt-Iib. Biochem.J., 473, 2016
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6HSF
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![BU of 6hsf by Molmil](/molmil-images/mine/6hsf) | Crystal structure of Schistosoma mansoni HDAC8 mutant H292M complexed with PCI-34051 | 分子名称: | 1-[(4-methoxyphenyl)methyl]-~{N}-oxidanyl-indole-6-carboxamide, DIMETHYLFORMAMIDE, GLYCEROL, ... | 著者 | Shaik, T.B, Marek, M, Romier, C. | 登録日 | 2018-10-01 | 公開日 | 2018-10-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
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1AU0
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![BU of 1au0 by Molmil](/molmil-images/mine/1au0) | CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC DIACYLAMINOMETHYL KETONE INHIBITOR | 分子名称: | 1,3-BIS[[N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL]AMINO]-2-PROPANONE, CATHEPSIN K | 著者 | Zhao, B, Smith, W.W, Janson, C.A, Abdel-Meguid, S.S. | 登録日 | 1997-09-09 | 公開日 | 1998-10-14 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and Design of Potent and Selective Cathepsin K Inhibitors J.Am.Chem.Soc., 119, 1997
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1B5T
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![BU of 1b5t by Molmil](/molmil-images/mine/1b5t) | ESCHERICHIA COLI METHYLENETETRAHYDROFOLATE REDUCTASE | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MERCURY (II) ION, PROTEIN (METHYLENETETRAHYDROFOLATE REDUCTASE) | 著者 | Guenther, B.D, Sheppard, C.A, Tran, P, Rozen, R, Matthews, R.G, Ludwig, M.L. | 登録日 | 1999-01-07 | 公開日 | 1999-01-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat.Struct.Biol., 6, 1999
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5LP8
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2VB5
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![BU of 2vb5 by Molmil](/molmil-images/mine/2vb5) | Solution structure of W60G mutant of human beta2-microglobulin | 分子名称: | BETA-2-MICROGLOBULIN | 著者 | Esposito, G, Corazza, A, Rennella, E, Gumral, D, Mimmi, M.C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M, Bellotti, V. | 登録日 | 2007-09-06 | 公開日 | 2007-09-25 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Controlling Roles of Trp60 and Trp95 in Beta2-Microglobulin Function, Folding and Amyloid Aggregation Properties. J.Mol.Biol., 378, 2008
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8H77
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![BU of 8h77 by Molmil](/molmil-images/mine/8h77) | Hsp90-AhR-p23-XAP2 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | 著者 | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | 登録日 | 2022-10-19 | 公開日 | 2023-01-04 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the cytosolic AhR complex. Structure, 31, 2023
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6N7U
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![BU of 6n7u by Molmil](/molmil-images/mine/6n7u) | apo-BDBV223 Fab | 分子名称: | BDBV223 antibody heavy chain, BDBV223 antibody light chain | 著者 | King, L.B, West, B.R, Saphire, E.O. | 登録日 | 2018-11-28 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun, 10, 2019
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6R2W
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![BU of 6r2w by Molmil](/molmil-images/mine/6r2w) | Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor | 分子名称: | CALCIUM ION, Coagulation factor VII, N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide, ... | 著者 | Sorensen, A.B, Svensson, L.A, Gandhi, P.S. | 登録日 | 2019-03-19 | 公開日 | 2019-12-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa. J.Biol.Chem., 295, 2020
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6GQ3
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![BU of 6gq3 by Molmil](/molmil-images/mine/6gq3) | Human asparagine synthetase (ASNS) in complex with 6-diazo-5-oxo-L-norleucine (DON) at 1.85 A resolution | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-OXO-L-NORLEUCINE, ... | 著者 | Zhu, W, Radadiya, A, Bisson, C, Jin, Y, Nordin, B.E, Imasaki, T, Wenzel, S, Sedelnikova, S.E, Berry, A.H, Nomanbhoy, T.K, Kozarich, J.W, Takagi, Y, Rice, D.W, Richards, N.G.J. | 登録日 | 2018-06-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity. Commun Biol, 2, 2019
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7UAI
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![BU of 7uai by Molmil](/molmil-images/mine/7uai) | Meprin alpha helix in complex with fetuin-B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C. | 登録日 | 2022-03-13 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor. Nat Commun, 13, 2022
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7LNA
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![BU of 7lna by Molmil](/molmil-images/mine/7lna) | Infectious mammalian prion fibril (263K scrapie) | 分子名称: | Major prion protein | 著者 | Kraus, A, Hoyt, F, Schwartz, C.L, Hansen, B, Hughson, A.G, Artikis, E, Race, B, Caughey, B. | 登録日 | 2021-02-06 | 公開日 | 2021-09-01 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | High-resolution structure and strain comparison of infectious mammalian prions. Mol.Cell, 81, 2021
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6GPJ
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![BU of 6gpj by Molmil](/molmil-images/mine/6gpj) | Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4F-Man | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, GDP-mannose 4,6 dehydratase, ... | 著者 | Pfeiffer, M, Krojer, T, Johansson, C, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Nidetzky, B, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2018-06-06 | 公開日 | 2018-07-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase. Acs Catalysis, 9, 2019
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8E0R
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![BU of 8e0r by Molmil](/molmil-images/mine/8e0r) | Crystal structure of mouse APCDD1 in P21 space group | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein APCDD1 | 著者 | Hsieh, F.L, Chang, T.H, Gabelli, S.B, Nathans, J. | 登録日 | 2022-08-09 | 公開日 | 2023-05-10 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein. Proc.Natl.Acad.Sci.USA, 120, 2023
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8I92
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![BU of 8i92 by Molmil](/molmil-images/mine/8i92) | ACE2-B0AT1 complex bound with glutamine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H. | 登録日 | 2023-02-06 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1. Cell Discov, 9, 2023
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5MQT
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![BU of 5mqt by Molmil](/molmil-images/mine/5mqt) | Crystal structure of dCK mutant C3S in complex with imatinib and UDP | 分子名称: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Deoxycytidine kinase, ... | 著者 | Saez-Ayala, M, Rebuffet, E, Hammam, K, Gros, L, Lopez, S, Hajem, B, Humbert, M, Baudelet, E, Audebert, S, Betzi, S, Lugari, A, Combes, S, Pez, D, Letard, S, Mansfield, C, Moussy, A, de Sepulveda, P, Morelli, X, Dubreuil, P. | 登録日 | 2016-12-20 | 公開日 | 2017-11-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology. Nat Commun, 8, 2017
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6K7V
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![BU of 6k7v by Molmil](/molmil-images/mine/6k7v) | Structure of NLRP1 CARD filament | 分子名称: | NACHT, LRR and PYD domains-containing protein 1 | 著者 | Gong, Q, Xu, C, Zhang, J, Wu, B. | 登録日 | 2019-06-09 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. Nat Commun, 12, 2021
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6CT7
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5UNI
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![BU of 5uni by Molmil](/molmil-images/mine/5uni) | |
6CDQ
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6NMI
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![BU of 6nmi by Molmil](/molmil-images/mine/6nmi) | Cryo-EM structure of the human TFIIH core complex | 分子名称: | CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription and DNA repair factor IIH helicase subunit XPD, ... | 著者 | Greber, B.J, Toso, D, Fang, J, Nogales, E. | 登録日 | 2019-01-10 | 公開日 | 2019-03-13 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | The complete structure of the human TFIIH core complex. Elife, 8, 2019
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5MMS
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![BU of 5mms by Molmil](/molmil-images/mine/5mms) | Human cystathionine beta-synthase (CBS) p.P49L delta409-551 variant | 分子名称: | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Vicente, J.B, Colaco, H.G, Malagrino, F, Santo, P.E, Gutierres, A, Bandeiras, T.M, Leandro, P, Brito, J.A, Giuffre, A. | 登録日 | 2016-12-12 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine beta-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxid Med Cell Longev, 2017, 2017
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1A8I
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![BU of 1a8i by Molmil](/molmil-images/mine/1a8i) | SPIROHYDANTOIN INHIBITOR OF GLYCOGEN PHOSPHORYLASE | 分子名称: | BETA-D-GLUCOPYRANOSE SPIROHYDANTOIN, GLYCOGEN PHOSPHORYLASE B | 著者 | Gregoriou, M, Noble, M.E.M, Watson, K.A, Garman, E.F, Krulle, T.M, De La Fuente, C, Fleet, G.W.J, Oikonomakos, N.G, Johnson, L.N. | 登録日 | 1998-03-25 | 公開日 | 1998-07-01 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding. Protein Sci., 7, 1998
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6NVC
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![BU of 6nvc by Molmil](/molmil-images/mine/6nvc) | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 6 | 分子名称: | ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, {(1S,2R)-2-[4-(carboxymethyl)benzene-1-carbonyl]cyclopentyl}acetic acid | 著者 | Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. | 登録日 | 2019-02-04 | 公開日 | 2020-02-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 6 To Be Published
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