5MQT
Crystal structure of dCK mutant C3S in complex with imatinib and UDP
Summary for 5MQT
Entry DOI | 10.2210/pdb5mqt/pdb |
Related | 5MQJ 5MQL |
Descriptor | Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (6 entities in total) |
Functional Keywords | deoxycytidine kinase, dck, masitinib, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P27707 |
Total number of polymer chains | 4 |
Total formula weight | 139335.33 |
Authors | Saez-Ayala, M.,Rebuffet, E.,Hammam, K.,Gros, L.,Lopez, S.,Hajem, B.,Humbert, M.,Baudelet, E.,Audebert, S.,Betzi, S.,Lugari, A.,Combes, S.,Pez, D.,Letard, S.,Mansfield, C.,Moussy, A.,de Sepulveda, P.,Morelli, X.,Dubreuil, P. (deposition date: 2016-12-20, release date: 2017-11-22, Last modification date: 2024-01-17) |
Primary citation | Hammam, K.,Saez-Ayala, M.,Rebuffet, E.,Gros, L.,Lopez, S.,Hajem, B.,Humbert, M.,Baudelet, E.,Audebert, S.,Betzi, S.,Lugari, A.,Combes, S.,Letard, S.,Casteran, N.,Mansfield, C.,Moussy, A.,De Sepulveda, P.,Morelli, X.,Dubreuil, P. Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology. Nat Commun, 8:1420-1420, 2017 Cited by PubMed: 29127277DOI: 10.1038/s41467-017-01582-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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