5MMS
Human cystathionine beta-synthase (CBS) p.P49L delta409-551 variant
Summary for 5MMS
Entry DOI | 10.2210/pdb5mms/pdb |
Descriptor | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total) |
Functional Keywords | cystathionine beta-synthase, hydrogen sulfide, transsulfuration, classical homocystinuria, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P35520 |
Total number of polymer chains | 6 |
Total formula weight | 273654.91 |
Authors | Vicente, J.B.,Colaco, H.G.,Malagrino, F.,Santo, P.E.,Gutierres, A.,Bandeiras, T.M.,Leandro, P.,Brito, J.A.,Giuffre, A. (deposition date: 2016-12-12, release date: 2017-05-03, Last modification date: 2024-01-17) |
Primary citation | Vicente, J.B.,Colaco, H.G.,Malagrino, F.,Santo, P.E.,Gutierres, A.,Bandeiras, T.M.,Leandro, P.,Brito, J.A.,Giuffre, A. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine beta-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxid Med Cell Longev, 2017:8940321-8940321, 2017 Cited by PubMed: 28421128DOI: 10.1155/2017/8940321 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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