PDB: 217686 件ウェブページステータス検索Chemie searchBIRD

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6S27	Crystal structure of human wild type STING in complex with 2'3'-cyclic-GMP-2'F-2'dAMP 分子名称: 2'3'-cyclic-GMP-2'F-2'dAMP, Stimulator of interferon protein 著者 Smola, M, Boura, E. 登録日 2019-06-20 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.802 Å) 主引用文献 Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations. J.Med.Chem., 62, 2019
7M06	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with R,R-bislysine bound at the allosteric site at 2.7 Angstrom 分子名称: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... 著者 Saran, S, Sanders, D.A.R. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS To Be Published
7RPR	Borrelia miyamotoi FbpA complement inhibitory domain 分子名称: Fibronectin-binding lipoprotein FbpA 著者 Booth, C.E, Garcia, B.L. 登録日 2021-08-04 公開日 2022-04-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions. Front Immunol, 13, 2022
1BMS	CRYSTAL STRUCTURE OF MS2 CAPSIDS WITH MUTATIONS IN THE SUBUNIT FG LOOP 分子名称: BACTERIOPHAGE MS2 CAPSID 著者 Liljas, L, Stonehouse, N.J. 登録日 1995-08-29 公開日 1996-03-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of MS2 capsids with mutations in the subunit FG loop. J.Mol.Biol., 256, 1996
6Z8Y	Copper transporter OprC 分子名称: Putative copper transport outer membrane porin OprC 著者 Bhamidimarri, S.P, van den Berg, B. 登録日 2020-06-02 公開日 2021-06-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site. Plos Biol., 19, 2021
6CJK	Anti HIV Fab 10A 分子名称: ACETATE ION, GLYCEROL, Immunoglobulin Fab heavy chain, ... 著者 Hangartner, L, Ward, A.B, Wilson, I.A, Oyen, D. 登録日 2018-02-26 公開日 2018-08-15 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (1.795 Å) 主引用文献 Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. Immunity, 49, 2018
4RPF	Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715 分子名称: CITRIC ACID, Homoserine kinase 著者 Ptskovsky, Y, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2014-10-30 公開日 2014-11-12 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715 To be Published
6HWH	Structure of a functional obligate respiratory supercomplex from Mycobacterium smegmatis 分子名称: CARDIOLIPIN, COPPER (II) ION, Co-purified unknown peptide built as polyALA, ... 著者 Wiseman, B, Nitharwal, R.G, Fedotovskaya, O, Schafer, J, Guo, H, Kuang, Q, Benlekbir, S, Sjostrand, D, Adelroth, P, Rubinstein, J.L, Brzezinski, P, Hogbom, M. 登録日 2018-10-12 公開日 2018-11-07 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of a functional obligate complex III2IV2respiratory supercomplex from Mycobacterium smegmatis. Nat. Struct. Mol. Biol., 25, 2018
6QJH	Cryo-EM structure of heparin-induced 2N4R tau snake filaments 分子名称: Microtubule-associated protein tau 著者 Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. 登録日 2019-01-24 公開日 2019-02-20 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
8DMN	Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates 分子名称: 3C-like proteinase nsp5 著者 Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J. 登録日 2022-07-08 公開日 2023-05-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023
6CZJ	Structure of a redesigned beta barrel, b10 分子名称: SULFATE ION, b10 著者 Doyle, L.A, Stoddard, B.L. 登録日 2018-04-09 公開日 2018-09-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 De novo design of a fluorescence-activating beta-barrel. Nature, 561, 2018
5JP3	Structure of Xanthomonas campestris effector protein XopD bound to ubiquitin 分子名称: Polyubiquitin-B, Xanthomonas outer protein D 著者 Pruneda, J.N, Komander, D. 登録日 2016-05-03 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases. Mol.Cell, 63, 2016
5JPO	Complex structure of human elongation factor 1B gamma GST-liked domain and delta N-terminal domain 分子名称: Elongation factor 1-delta, Elongation factor 1-gamma, GLYCEROL 著者 Choi, Y.S, Kang, B.S. 登録日 2016-05-04 公開日 2017-05-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Complex structure of human elongation factor 1B gamma GST-liked domain and delta N-terminal domain To Be Published
6NVB	Crystal structure of the inhibitor-free form of the serine protease kallikrein-4 分子名称: GLYCEROL, Kallikrein-4, SULFATE ION 著者 Riley, B.T, Buckle, A.M, McGowan, S. 登録日 2019-02-04 公開日 2019-07-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.636 Å) 主引用文献 Crystal structure of the inhibitor-free form of the serine protease kallikrein-4. Acta Crystallogr.,Sect.F, 75, 2019
6ZLG	Folding of an iron binding peptide in response to sedimentation is resolved using ferritin as a nano-reactor 分子名称: Ferritin 著者 Davidov, G, Abelya, G, Zalk, R, Izbicki, B, Shaibi, S, Spektor, L, Meyron Holtz, E.G, Zarivach, R, Frank, G.A. 登録日 2020-06-30 公開日 2021-07-07 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Folding of an Intrinsically Disordered Iron-Binding Peptide in Response to Sedimentation Revealed by Cryo-EM. J.Am.Chem.Soc., 142, 2020
6CEK	Crystal structure of the D141N variant of catalase-peroxidase from B. pseudomallei 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Catalase-peroxidase, ... 著者 Loewen, P.C. 登録日 2018-02-12 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the D141N variant of catalase-peroxidase from B. pseudomallei To be published
6NOW	Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain 分子名称: Alanine--tRNA ligase, mitochondrial 著者 Kuhle, B, Schimmel, P. 登録日 2019-01-16 公開日 2020-01-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.099 Å) 主引用文献 Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs. Nat Commun, 11, 2020
5EK5	STRUCTURAL CHARACTERIZATION OF IRMA FROM ESCHERICHIA COLI 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, FORMIC ACID, ... 著者 Heras, B, Moriel, D.G, Paxman, J.J, Schembri, M.A. 登録日 2015-11-03 公開日 2016-03-09 最終更新日 2016-07-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein. Mbio, 7, 2016
7D8C	Crystal structure of the Cas12i1-crRNA binary complex 分子名称: 12i1, CITRIC ACID, RNA (3-MER), ... 著者 Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. 登録日 2020-10-07 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1. Nat Commun, 12, 2021
462D	CRYSTAL STRUCTURE OF THE HIV-1 GENOMIC RNA DIMERIZATION INITIATION SITE 分子名称: MAGNESIUM ION, RNA (5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G) -3') 著者 Ennifar, E, Yusupov, M, Walter, P, Marquet, R, Ehresmann, C, Ehresmann, B, Dumas, P. 登録日 1999-03-18 公開日 1999-12-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges. Structure Fold.Des., 7, 1999
8V8Z	Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3473329 分子名称: Apolipoprotein(a), muvalaplin 著者 Hendle, J, Weichert, K, Sauder, J.M. 登録日 2023-12-06 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature, 629, 2024
5EPK	Crystal Structure of chromodomain of CBX2 in complex with inhibitor UNC3866 分子名称: Chromobox protein homolog 2, UNKNOWN ATOM OR ION, unc3866 著者 Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2015-11-11 公開日 2015-12-23 最終更新日 2019-11-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat.Chem.Biol., 12, 2016
6TJX	Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration 分子名称: Microtubule-associated protein tau 著者 Zhang, W, Murzin, A.G, Falcon, B, Shi, Y, Goedert, M, Scheres, S.H.W. 登録日 2019-11-27 公開日 2020-02-05 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Novel tau filament fold in corticobasal degeneration. Nature, 580, 2020
6HFX	Crystal structure of Extracellular Domain 1 (ECD1) of FtsX from S. pneumonie in complex with n-decyl-B-D-maltoside 分子名称: Cell division protein FtsX, DECYL-BETA-D-MALTOPYRANOSIDE 著者 Alcorlo Pages, M, Martinez-Caballero, S. 登録日 2018-08-22 公開日 2019-04-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae. Mbio, 10, 2019
5M6U	HUMAN PI3KDELTA IN COMPLEX WITH LASW1579 分子名称: 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 著者 Segarra, V, Hernandez, B, Lozoya, E, Blaesse, M, Hoeppner, S, Jestel, A. 登録日 2016-10-26 公開日 2017-02-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett, 8, 2017

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