5M6U
HUMAN PI3KDELTA IN COMPLEX WITH LASW1579
Summary for 5M6U
Entry DOI | 10.2210/pdb5m6u/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile (3 entities in total) |
Functional Keywords | pi3kdelta kinase, proteros biostructures gmbh, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 199769.15 |
Authors | Segarra, V.,Hernandez, B.,Lozoya, E.,Blaesse, M.,Hoeppner, S.,Jestel, A. (deposition date: 2016-10-26, release date: 2017-02-01, Last modification date: 2024-01-17) |
Primary citation | Erra, M.,Taltavull, J.,Greco, A.,Bernal, F.J.,Caturla, J.F.,Gracia, J.,Dominguez, M.,Sabate, M.,Paris, S.,Soria, S.,Hernandez, B.,Armengol, C.,Cabedo, J.,Bravo, M.,Calama, E.,Miralpeix, M.,Lehner, M.D. Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases. ACS Med Chem Lett, 8:118-123, 2017 Cited by PubMed: 28105286DOI: 10.1021/acsmedchemlett.6b00438 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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