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5M6U

HUMAN PI3KDELTA IN COMPLEX WITH LASW1579

Functional Information from GO Data
ChainGOidnamespacecontents
A0001779biological_processnatural killer cell differentiation
A0001819biological_processpositive regulation of cytokine production
A0001938biological_processpositive regulation of endothelial cell proliferation
A0002250biological_processadaptive immune response
A0002551biological_processmast cell chemotaxis
A0002679biological_processrespiratory burst involved in defense response
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005942cellular_componentphosphatidylinositol 3-kinase complex
A0005943cellular_componentphosphatidylinositol 3-kinase complex, class IA
A0006468biological_processprotein phosphorylation
A0006629biological_processlipid metabolic process
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0010818biological_processT cell chemotaxis
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0016310biological_processphosphorylation
A0030101biological_processnatural killer cell activation
A0030154biological_processcell differentiation
A0030183biological_processB cell differentiation
A0030217biological_processT cell differentiation
A0030335biological_processpositive regulation of cell migration
A0030593biological_processneutrophil chemotaxis
A0033031biological_processpositive regulation of neutrophil apoptotic process
A0035005molecular_function1-phosphatidylinositol-4-phosphate 3-kinase activity
A0035747biological_processnatural killer cell chemotaxis
A0035754biological_processB cell chemotaxis
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0038084biological_processvascular endothelial growth factor signaling pathway
A0042110biological_processT cell activation
A0042113biological_processB cell activation
A0043303biological_processmast cell degranulation
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0045087biological_processinnate immune response
A0045766biological_processpositive regulation of angiogenesis
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0046934molecular_function1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
A0048015biological_processphosphatidylinositol-mediated signaling
A0050852biological_processT cell receptor signaling pathway
A0050853biological_processB cell receptor signaling pathway
A0060374biological_processmast cell differentiation
A0072672biological_processneutrophil extravasation
A1905278biological_processpositive regulation of epithelial tube formation
B0001678biological_processintracellular glucose homeostasis
B0001784molecular_functionphosphotyrosine residue binding
B0001953biological_processnegative regulation of cell-matrix adhesion
B0002687biological_processpositive regulation of leukocyte migration
B0005068molecular_functiontransmembrane receptor protein tyrosine kinase adaptor activity
B0005158molecular_functioninsulin receptor binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005168molecular_functionneurotrophin TRKA receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005801cellular_componentcis-Golgi network
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005942cellular_componentphosphatidylinositol 3-kinase complex
B0005943cellular_componentphosphatidylinositol 3-kinase complex, class IA
B0006366biological_processtranscription by RNA polymerase II
B0006606biological_processprotein import into nucleus
B0006955biological_processimmune response
B0007162biological_processnegative regulation of cell adhesion
B0007165biological_processsignal transduction
B0008286biological_processinsulin receptor signaling pathway
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010592biological_processpositive regulation of lamellipodium assembly
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0019209molecular_functionkinase activator activity
B0019221biological_processcytokine-mediated signaling pathway
B0019903molecular_functionprotein phosphatase binding
B0030183biological_processB cell differentiation
B0030217biological_processT cell differentiation
B0030316biological_processosteoclast differentiation
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032869biological_processcellular response to insulin stimulus
B0033120biological_processpositive regulation of RNA splicing
B0034143biological_processregulation of toll-like receptor 4 signaling pathway
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0034644biological_processcellular response to UV
B0034976biological_processresponse to endoplasmic reticulum stress
B0035014molecular_functionphosphatidylinositol 3-kinase regulator activity
B0035655biological_processinterleukin-18-mediated signaling pathway
B0036312molecular_functionphosphatidylinositol 3-kinase regulatory subunit binding
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042307biological_processpositive regulation of protein import into nucleus
B0043066biological_processnegative regulation of apoptotic process
B0043125molecular_functionErbB-3 class receptor binding
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0043548molecular_functionphosphatidylinositol 3-kinase binding
B0043559molecular_functioninsulin binding
B0043560molecular_functioninsulin receptor substrate binding
B0045671biological_processnegative regulation of osteoclast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046326biological_processpositive regulation of glucose import
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0046935molecular_function1-phosphatidylinositol-3-kinase regulator activity
B0046982molecular_functionprotein heterodimerization activity
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050821biological_processprotein stabilization
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051497biological_processnegative regulation of stress fiber assembly
B0052742molecular_functionphosphatidylinositol kinase activity
B0060396biological_processgrowth hormone receptor signaling pathway
B0097529biological_processmyeloid leukocyte migration
B0120183biological_processpositive regulation of focal adhesion disassembly
B0140767molecular_functionenzyme-substrate adaptor activity
B0141038molecular_functionphosphatidylinositol 3-kinase activator activity
B1900103biological_processpositive regulation of endoplasmic reticulum unfolded protein response
B1903076biological_processregulation of protein localization to plasma membrane
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1990578cellular_componentperinuclear endoplasmic reticulum membrane
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue 7KA A 1101
ChainResidue
APRO758
ATRP760
ATYR813
AILE825
AGLU826
AVAL828
AASP832
AMET900
AILE910

Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKng.DDLRQDmltlQ
ChainResidueDetails
APHE778-GLN792

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatYVLgIgDRHsdN
ChainResidueDetails
ASER878-ASN898

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378
ChainResidueDetails
BSER2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER154
BSER279

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P26450
ChainResidueDetails
BTYR467

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
BTYR580

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23727
ChainResidueDetails
BSER608

223166

PDB entries from 2024-07-31

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