PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

---

6DIS	Crystal structure of HCV NS3/4A protease in complex with P4-1 (AJ-71) 分子名称: 1,1,1-trifluoro-2-methylpropan-2-yl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5, 16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6- yl]carbamate, GLYCEROL, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.921 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
6PA1	Killer cell immunoglobulin-like receptor 2DL2 in complex with HLA-C*07:02 分子名称: ARG-TYR-ARG-PRO-GLY-THR-VAL-ALA-LEU, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... 著者 Moradi, S, Rossjohn, J, Vivian, J.P. 登録日 2019-06-11 公開日 2020-12-16 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nat Commun, 12, 2021
6PAG	Killer cell immunoglobulin-like receptor 2DL3 in complex with HLA-C*07:02 分子名称: ARG-TYR-ARG-PRO-GLY-THR-VAL-ALA-LEU, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... 著者 Moradi, S, Rossjohn, J, Vivian, J.P. 登録日 2019-06-11 公開日 2020-12-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nat Commun, 12, 2021
8DZL	Structure of the K39Q mutant of rat somatic Cytochrome c at 1.36A 分子名称: Cytochrome c, somatic, HEME C 著者 Edwards, B.F.P, Huettemann, M, Vaishnav, A, Brunzelle, J, Morse, P, Wan, J. 登録日 2022-08-08 公開日 2023-07-19 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle. Nat Commun, 14, 2023
6DIQ	Crystal structure of HCV NS3/4A protease in complex with P4-P5-1 (WK-23) 分子名称: GLYCEROL, NS3 protease, SULFATE ION, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.579 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
6DIW	Crystal structure of HCV NS3/4A D168A protease in complex with P4-1 (AJ-71) 分子名称: 1,1,1-trifluoro-2-methylpropan-2-yl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5, 16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6- yl]carbamate, GLYCEROL, ... 著者 Matthew, A.N, Schiffer, C.A. 登録日 2018-05-23 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope To Be Published
6XNK	Crystal structure of dimeric K72A human cytochrome c alkaline conformer 分子名称: Cytochrome c, HEME C 著者 Lei, H, Bowler, B.E. 登録日 2020-07-03 公開日 2021-07-07 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Alkaline State of the Domain-Swapped Dimer of Human Cytochrome c : A Conformational Switch for Apoptotic Peroxidase Activity. J.Am.Chem.Soc., 2022
9HUA	Glycosyltransferase C from the Limosilactobacillus reuteri accessory secretion system. Complex with UDP. 分子名称: Glucosyltransferase 3, URIDINE-5'-DIPHOSPHATE 著者 Asworth, G.J, Griffiths, R, Juge, N, Dong, C.J, Hemmings, A.M. 登録日 2024-12-21 公開日 2025-04-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A structural basis for the strain-dependent UDP-sugar specificity of glycosyltransferase C from the Limosilactobacillus reuteri accessory secretion system To Be Published
5KZP	Structure of the HCV1-C1 Antibody-Antigen Complex 分子名称: ACETATE ION, C1 Epitope, CALCIUM ION, ... 著者 Piepenbrink, K.H, Sundberg, E.J. 登録日 2016-07-25 公開日 2017-07-05 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.262 Å) 主引用文献 Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope. J. Virol., 91, 2017
6Y57	Structure of human ribosome in hybrid-PRE state 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. 登録日 2020-02-25 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes. Cell Rep, 31, 2020
6VD9	Metal-bound C-terminal domain of the CzcD transporter from Cuprividus metallidurans 分子名称: Metal cation efflux system protein CzcD, NICKEL (II) ION 著者 Maher, M.J. 登録日 2019-12-23 公開日 2020-06-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and functional characterizations of the C-terminal domains of CzcD proteins. J.Inorg.Biochem., 208, 2020
6GC5	Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM 分子名称: AU-rich RNA, ELAV-like protein 1 著者 Ripin, N, Allain, F.H. 登録日 2018-04-17 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8WCT	The crystal structure of the CHASE4 domain of iron-sensetive membrane protein (IsmP,Uniprot ID:Q9I243) 分子名称: Bifunctional diguanylate cyclase/phosphodiesterase, GLYCEROL 著者 Wang, C.C. 登録日 2023-09-13 公開日 2024-02-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. Nat Commun, 15, 2024
8WCN	Cryo-EM structure of PAO1-ImcA with GMPCPP 分子名称: Diguanylate cyclase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Zhan, X.L, Zhang, K, Wang, C.C, Fan, Q, Tang, X.J, Zhang, X, Wang, K, Fu, Y, Liang, H.H. 登録日 2023-09-13 公開日 2024-03-13 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. Nat Commun, 15, 2024
5LXV	Crystal structure of Ruminococcus flavefaciens scaffoldin C cohesin in complex with a dockerin from an uncharacterized CBM-containing protein 分子名称: CALCIUM ION, Carbohydrate-binding protein WP_009985128, Scaffoldin C 著者 Najmudin, S, Bule, P, Fontes, C.M.G.A. 登録日 2016-09-22 公開日 2016-10-19 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Single Binding Mode Integration of Hemicellulose-degrading Enzymes via Adaptor Scaffoldins in Ruminococcus flavefaciens Cellulosome. J. Biol. Chem., 291, 2016
7UN8	SfSTING with c-di-GMP single fiber 分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12 著者 Morehouse, B.R, Yip, M.C.J, Keszei, A.F.A, McNamara-Bordewick, N.K, Shao, S, Kranzusch, P.J. 登録日 2022-04-09 公開日 2022-07-27 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of an active bacterial TIR-STING filament complex. Nature, 608, 2022
7UN9	SfSTING with c-di-GMP double fiber 分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12 著者 Morehouse, B.R, Yip, M.C.J, Keszei, A.F.A, McNamara-Bordewick, N.K, Shao, S, Kranzusch, P.J. 登録日 2022-04-09 公開日 2022-07-27 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of an active bacterial TIR-STING filament complex. Nature, 608, 2022
5D9G	Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide 分子名称: CHLORIDE ION, NICKEL (II) ION, PHOSPHATE ION, ... 著者 Scorsato, V, Sandy, J, Brandao-Neto, J, Pereira, H.M, Smetana, J.H.C, Aparicio, R. 登録日 2015-08-18 公開日 2016-08-10 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus. Sci Rep, 6, 2016
9CZ2	Cryo-EM structure of a nautilus-like HflK/C assembly in complex with FtsH AAA protease 分子名称: ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Modulator of FtsH protease HflK 著者 Ghanbarpour, A, Sauer, R.T, Davis, J.H. 登録日 2024-08-03 公開日 2024-11-13 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins. Embo J., 44, 2025
6SX4	Structure of C. glutamicum mycoloyltransferase A 分子名称: ACETATE ION, Protein PS1 著者 Li de la Sierra-Gallay, I, Van tilbeurgh, H, Bayan, N. 登録日 2019-09-24 公開日 2020-03-04 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.796 Å) 主引用文献 The C-terminal domain of Corynebacterium glutamicum mycoloyltransferase A is composed of five repeated motifs involved in cell wall binding and stability. Mol.Microbiol., 114, 2020
9DF3	EGFR Exon20 insertion mutant SVD bound with (S)-3-((3-chloro-2-methoxyphenyl)amino)-2-(3-((tetrahydrofuran-2-yl)methoxy)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one 分子名称: 1,2-ETHANEDIOL, 3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[[(2S)-oxolan-2-yl]methoxy]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Epidermal growth factor receptor, ... 著者 Hilbert, B.J, Brooijmans, N, Pagliarini, R.A, Milgram, B.C. 登録日 2024-08-29 公開日 2025-05-14 最終更新日 2025-06-11 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models. Clin.Cancer Res., 2025
9EHY	X-ray crystal structure of ADC-33 beta-lactamase in complex with ceftazidime in acyl and product forms 分子名称: (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ACYLATED CEFTAZIDIME, Beta-lactamase 著者 Powers, R.A, Wallar, B.J, Jarvis, H.R, Ziegler, Z.X, June, C.M. 登録日 2024-11-25 公開日 2025-05-14 最終更新日 2025-06-25 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C beta-lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab ). Mbio, 16, 2025
8QRI	TRRAP and EP400 in the human Tip60 complex 分子名称: E1A-binding protein p400, Transformation/transcription domain-associated protein 著者 Li, C, Smirnova, E, Schnitzler, C, Crucifix, C, Concordet, J.P, Brion, A, Poterszman, A, SChultz, P, Papai, G, Ben-Shem, A. 登録日 2023-10-09 公開日 2024-08-07 最終更新日 2024-12-04 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the human TIP60-C histone exchange and acetyltransferase complex. Nature, 635, 2024
6XFS	Class C beta-lactamase from Escherichia coli in complex with Tazobactam 分子名称: 1,2-ETHANEDIOL, Beta-lactamase, DI(HYDROXYETHYL)ETHER, ... 著者 Chang, C, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-06-16 公開日 2020-07-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Class C beta-lactamase from Escherichia coli in complex with Tazobactam To Be Published
6N5W	Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A & B domains 分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4 著者 Taylor, A.B, Archer, C.R, Shapiro, M.S. 登録日 2018-11-22 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A mutually induced conformational fit underlies Ca2+-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K+channels. J. Biol. Chem., 294, 2019

<54555657585960616263646566676869>