9EHY

X-ray crystal structure of ADC-33 beta-lactamase in complex with ceftazidime in acyl and product forms

This is a non-PDB format compatible entry.

Summary for 9EHY

• Entry DOI: 10.2210/pdb9ehy/pdb
• Descriptor: Beta-lactamase, (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ACYLATED CEFTAZIDIME, ... (4 entities in total)
• Functional Keywords: lactamase, complex, cephalosporin, ceftazidime, hydrolase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 2
• Total formula weight: 83069.58

Authors

Powers, R.A.,Wallar, B.J.,Jarvis, H.R.,Ziegler, Z.X.,June, C.M. (deposition date: 2024-11-25, release date: 2025-05-14)

• Primary citation: Powers, R.A.,Wallar, B.J.,Jarvis, H.R.,Ziegler, Z.X.,June, C.M.,Bethel, C.R.,Hujer, A.M.,Taracila, M.A.,Rudin, S.D.,Hujer, K.M.,Prati, F.,Caselli, E.,Bonomo, R.A.; Expanded-spectrum hydrolysis by Acinetobacter Derived Cephalosporinase-33 (ADC-33), a class C beta-lactamase present in carbapenem-resistant Acinetobacter baumannii (CRAb); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.57 Å)