PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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7U7Y	Human DNA polymerase eta-DNA-dGMPNPP ternary mismatch complex in 0.06 mM Mn2+ for 600s 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-03-07 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 In crystallo observation of three metal ion promoted DNA polymerase misincorporation. Nat Commun, 13, 2022
7U84	Human DNA polymerase eta-DNA-dGMPNPP ternary mismatch complex in 6.0 mM Mn2+ for 600s 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-03-07 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 In crystallo observation of three metal ion promoted DNA polymerase misincorporation. Nat Commun, 13, 2022
7U73	Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 0.5 mM Mn2+ for 1800s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-03-07 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 In crystallo observation of three metal ion promoted DNA polymerase misincorporation. Nat Commun, 13, 2022
7U7G	Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 10.0 mM Mn2+ for 120s 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-03-07 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 In crystallo observation of three metal ion promoted DNA polymerase misincorporation. Nat Commun, 13, 2022
7U82	Human DNA polymerase eta-DNA-dGMPNPP ternary mismatch complex in 1.0 mM Mn2+ for 600s 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2022-03-07 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 In crystallo observation of three metal ion promoted DNA polymerase misincorporation. Nat Commun, 13, 2022
7Z6L	Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB 分子名称: (2~{S},4~{R})-~{N}-[[2-[3-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Roy, M.J, Bader, G, Farnaby, W, Ciulli, A. 登録日 2022-03-12 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
8W7M	Yeast replisome in state V 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (71-mer), ... 著者 Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. 登録日 2023-08-30 公開日 2023-12-06 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
8W7S	Yeast replisome in state IV 分子名称: Cell division control protein 45, DNA (71-mer), DNA polymerase alpha-binding protein, ... 著者 Dang, S, Zhai, Y, Feng, J, Yu, D. 登録日 2023-08-31 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (7.39 Å) 主引用文献 Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
8B77	The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... 著者 Parkash, V, Johansson, E. 登録日 2022-09-29 公開日 2023-10-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
8FTK	Chaetomium thermophilum SETX (Full-length) 分子名称: 5'-3' RNA helicase-like protein 著者 Williams, R.S, Appel, C.D. 登録日 2023-01-12 公開日 2023-10-25 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (4.56 Å) 主引用文献 Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2. Mol.Cell, 83, 2023
6HV9	S. cerevisiae CMG-Pol epsilon-DNA 分子名称: Cell division control protein 45, DNA (5'-D(*GP*CP*AP*GP*CP*CP*AP*CP*GP*CP*TP*GP*GP*CP*CP*GP*TP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*AP*CP*GP*GP*CP*CP*AP*GP*CP*GP*TP*GP*GP*CP*TP*GP*C)-3'), ... 著者 Abid Ali, F, Purkiss, A.G, Cheung, A, Costa, A. 登録日 2018-10-10 公開日 2018-12-12 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (4.98 Å) 主引用文献 Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome. Nat Commun, 9, 2018
6EUY	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor 分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION 著者 Cusack, S, Gaudon, S. 登録日 2017-10-31 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
3FWB	Sac3:Sus1:Cdc31 complex 分子名称: Cell division control protein 31, Nuclear mRNA export protein SAC3, Protein SUS1 著者 Stewart, M, Jani, D. 登録日 2009-01-17 公開日 2009-04-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol.Cell, 33, 2009
8B7E	The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active site 分子名称: CALCIUM ION, DNA polymerase epsilon catalytic subunit A, GLYCEROL, ... 著者 Parkash, V, Johansson, E. 登録日 2022-09-29 公開日 2023-10-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
3C2K	DNA POLYMERASE BETA with a gapped DNA substrate and DUMPNPP with Manganese in the active site 分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), ... 著者 Batra, V.K, Beard, W.A, Shock, D.D, Pedersen, L.C, Wilson, S.H. 登録日 2008-01-25 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol.Cell, 30, 2008
4C31	Nup1:Sac3:Sus1 complex 分子名称: NUCLEAR MRNA EXPORT PROTEIN SAC3, NUCLEOPORIN NUP1, PROTEIN SUS1 著者 Stewart, M, Jani, D. 登録日 2013-08-21 公開日 2014-04-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Basis for Binding the Trex2 Complex to Nuclear Pores, Gal1 Localisation and Mrna Export. Nucleic Acids Res., 42, 2014
6FBI	KlenTaq DNA polymerase in a closed, ternary complex with dGpNHpp bound in the active site 分子名称: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... 著者 Kropp, H.M, Diederichs, K, Marx, A. 登録日 2017-12-19 公開日 2018-09-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3PY8	Crystal structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in a closed ternary complex with DNA and ddCTP 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*A*AP*GP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... 著者 Schnur, A, Marx, A, Welte, W, Diederichs, K. 登録日 2010-12-12 公開日 2011-06-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity. Chembiochem, 12, 2011
3FWC	Sac3:Sus1:Cdc31 complex 分子名称: Cell division control protein 31, Nuclear mRNA export protein SAC3, Protein SUS1, ... 著者 Stewart, M, Jani, D. 登録日 2009-01-17 公開日 2009-04-14 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol.Cell, 33, 2009
2P40	Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, SULFATE ION, type II methyltransferase 著者 Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2007-03-11 公開日 2007-08-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5 J.Mol.Biol., 372, 2007
2JLR	Dengue virus 4 NS3 helicase in complex with AMPPNP 分子名称: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE PROTEASE SUBUNIT NS3 著者 Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. 登録日 2008-09-15 公開日 2008-11-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
7WV3	Toll-like receptor3 linear cluster 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (80-MER), ... 著者 Lim, C.S, Jang, Y.H, Lee, G.Y, Han, G.M, Lee, J.O. 登録日 2022-02-09 公開日 2022-11-16 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (2.26 Å) 主引用文献 TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand. Nat Commun, 13, 2022
6EUW	Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor 分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2 著者 Cusack, S, Gaudon, S. 登録日 2017-10-31 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
2JLS	Dengue virus 4 NS3 helicase in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... 著者 Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. 登録日 2008-09-15 公開日 2008-11-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein. Embo J., 27, 2008
6Q4T	KOD DNA pol in a closed ternary complex with 7-deaza-7-(2-(2-hydroxyethoxy)-N-(prop-2-yn-1-yl)acetamide)-2-dATP 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), DNA (5'-D(P*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... 著者 Kropp, H.M, Diederichs, K, Marx, A. 登録日 2018-12-06 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide. Angew.Chem.Int.Ed.Engl., 58, 2019

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