PDB: 73050 件ウェブページステータス検索Chemie searchBIRD

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5U78	Crystal structure of ORP8 PH domain in P1211 space group 分子名称: Oxysterol-binding protein-related protein 8 著者 Ghai, R, Yang, H. 登録日 2016-12-12 公開日 2017-10-18 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane. Nat Commun, 8, 2017
8TIB	Cryo-EM of tri-pilus from S. islandicus REY15A 分子名称: DUF973 family protein 著者 Eastep, G.N, Liu, J, Rich-New, S.T, Egelman, E.H, Krupovic, M, Wang, F. 登録日 2023-07-19 公開日 2024-01-10 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Two distinct archaeal type IV pili structures formed by proteins with identical sequence. Nat Commun, 15, 2024
8TIF	Cryo-EM of mono-pilus from S. islandicus REY15A 分子名称: DUF973 family protein 著者 Eastep, G.N, Liu, J, Rich-New, S.T, Egelman, E.H, Krupovic, M, Wang, F. 登録日 2023-07-19 公開日 2024-01-10 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Two distinct archaeal type IV pili structures formed by proteins with identical sequence. Nat Commun, 15, 2024
6KTW	structure of EanB with hercynine 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... 著者 Wu, L, Liu, P.H, Zhou, J.H. 登録日 2019-08-29 公開日 2020-08-26 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.931 Å) 主引用文献 Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
5TUV	Crystal structure of the E2F5-DP1-p107 ternary complex 分子名称: Retinoblastoma-like protein 1, Transcription factor DP1, Transcription factor E2F5 著者 Liban, T.J, Tripathi, S.M, Rubin, S.M. 登録日 2016-11-07 公開日 2017-05-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6C0M	The synthesis, biological evaluation and structural insights of unsaturated 3-N-substituted sialic acids as probes of human parainfluenza virus-3 haemagglutinin-neuraminidase 分子名称: 1,2-ETHANEDIOL, 2,6-anhydro-3,5-dideoxy-5-[(2-methylpropanoyl)amino]-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-D-glycero-D-galacto-non-2-enoni c acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dirr, L, Ve, T, von Itzstein, M. 登録日 2018-01-01 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes. ACS Chem. Biol., 13, 2018
8TC8	Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate 分子名称: 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
8TC9	Human asparaginyl-tRNA synthetase bound to OSM-S-106 分子名称: Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
8U1F	FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10 分子名称: Fibroblast growth factor receptor 2, GLYCEROL, N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide, ... 著者 Valverde, R, Foster, L. 登録日 2023-08-31 公開日 2024-02-14 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121, 2024
8TC7	Human asparaginyl-tRNA synthetase, apo form 分子名称: Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
5UJ6	Crystal Structure of Bacteroides Uniformis beta-glucuronidase 分子名称: CALCIUM ION, GLYCEROL, Glycosyl hydrolases family 2, ... 著者 Walton, W.G, Redinbo, M.R. 登録日 2017-01-17 公開日 2017-06-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 An Atlas of beta-Glucuronidases in the Human Intestinal Microbiome. Structure, 25, 2017
5V3X	Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM1 分子名称: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-4-[(4-methylpiperidin-1-yl)methyl]-2-phenyl-1-benzofuran-3-carboxylate 著者 Aggarwal, A, Sacchettini, J.C. 登録日 2017-03-08 公開日 2017-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.936 Å) 主引用文献 Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell, 170, 2017
5V7A	E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-((2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)acetic acid 分子名称: CHLORIDE ION, Dihydropteroate synthase, [(2-amino-9-methyl-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]acetic acid 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2017-03-20 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase. Chemistry, 24, 2018
5UQ3	Crystal structure of human Cdk2-Spy1-P27 ternary complex 分子名称: Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
6C6M	IgCam3 of human MLCK1 分子名称: Myosin light chain kinase, smooth muscle 著者 Zuccola, H.J, Turner, J. 登録日 2018-01-19 公開日 2019-01-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat. Med., 25, 2019
6BWV	Crystal Structure of the 4-1BB/4-1BBL Complex 分子名称: DI(HYDROXYETHYL)ETHER, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 著者 Oganesyan, V, Gilbreth, R.N, Baca, M. 登録日 2017-12-15 公開日 2018-05-09 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the human 4-1BB/4-1BBL complex. J. Biol. Chem., 293, 2018
8TM0	Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class I polypeptide-related sequence A, ... 著者 Rupert, P.B, Strong, R. 登録日 2023-07-27 公開日 2024-04-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.83 Å) 主引用文献 Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10, 2024
6BVH	Trypsin complexed with a modified sunflower trypsin inhibitor, SFTI-TCTR(N12,N14) 分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ... 著者 Riley, B.T, Chen, X. 登録日 2017-12-13 公開日 2018-12-19 最終更新日 2019-01-30 実験手法 X-RAY DIFFRACTION (1.927 Å) 主引用文献 Potent, multi-target serine protease inhibition achieved by a simplified beta-sheet motif. PLoS ONE, 14, 2019
8TM2	Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Rupert, P.B, Strong, R. 登録日 2023-07-27 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10, 2024
8TLZ	Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys 分子名称: (2S)-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Rupert, P.B, Strong, R. 登録日 2023-07-27 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10, 2024
6DIC	D276G DNA polymerase beta substrate complex with templating cytosine and incoming Fapy-dGTP analog 分子名称: 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol, CALCIUM ION, CHLORIDE ION, ... 著者 Freudenthal, B.D, Smith, M.R, Wilson, S.H, Beard, W.A. 登録日 2018-05-23 公開日 2019-01-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.992 Å) 主引用文献 A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Res., 47, 2019
5VY2	Crystal structure of the F36A mutant of HsNUDT16 分子名称: SODIUM ION, U8 snoRNA-decapping enzyme 著者 Thirawatananond, P, Gabelli, S.B. 登録日 2017-05-24 公開日 2018-11-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep, 9, 2019
5VCJ	Structure of alpha-galactosylphytosphingosine bound by CD1d and in complex with the Va14Vb8.2 TCR 分子名称: (2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl alpha-D-galactopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... 著者 Wang, J, Zajonc, D.M. 登録日 2017-03-31 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist. Org. Biomol. Chem., 17, 2019
1YME	STRUCTURE OF CARBOXYPEPTIDASE 分子名称: CARBOXYPEPTIDASE A ALPHA, ZINC ION 著者 Greenblatt, H.M, Tucker, P.A, Shoham, G. 登録日 1996-07-15 公開日 1997-02-12 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Carboxypeptidase A: native, zinc-removed and mercury-replaced forms. Acta Crystallogr.,Sect.D, 54, 1998
6DUK	EGFR with an allosteric inhibitor 分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... 著者 Park, E, Eck, M.J. 登録日 2018-06-21 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov, 9, 2019

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