8TLZ

Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys

Summary for 8TLZ

• Entry DOI: 10.2210/pdb8tlz/pdb
• Descriptor: MHC class I polypeptide-related sequence A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-2-hydroxybutanedioic acid, ... (6 entities in total)
• Functional Keywords: modified mica, ligand nkg2d, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46044.19

Authors

Rupert, P.B.,Strong, R. (deposition date: 2023-07-27, release date: 2024-04-17, Last modification date: 2024-11-13)

Primary citation

Rupert, P.B.,Buerger, M.,Girard, E.J.,Frutoso, M.,Parrilla, D.,Ng, K.,Gooley, T.,Groh, V.,Strong, R.K.
Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys.
Heliyon, 10:e28583-e28583, 2024

PubMed Abstract: NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediated effector functions. However, this axis can drive disease processes when dysregulated, in particular, driving stem-like cancer cell reprogramming and tumorigenesis through receptor/ligand self-stimulation on tumor cells. Despite complexities with its structure and biology, we developed multiple novel engineered proteins that functionally serve as axis-blocking NKG2D "decoys" and report biochemical, structural, , and evaluation of their functionality.

PubMed: 38586421
DOI: 10.1016/j.heliyon.2024.e28583

Experimental method

X-RAY DIFFRACTION (2.75 Å)