8TLZ

Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	MHC class I polypeptide-related sequence A	polymer	188	22144.8	2	UniProt (Q29983) Pfam (PF00129)	Homo sapiens (human)
2	C, D (C, D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
3	E, H (A, B)	(2S)-2-hydroxybutanedioic acid	non-polymer		134.1	2	Chemie (LMR)
4	F (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	G (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	I, J (A, B)	water	water		18.0	50	Chemie (HOH)

Sequence modifications

A, B: 1 - 182 (UniProt: Q29983)

PDB	External Database	Details
Trp 69	Asn 92	conflict
Leu 125	Lys 148	conflict
Glu 152	Lys 175	conflict
Asp 154	Lys 177	conflict
Arg 161	His 184	conflict
Ser 166	Gln 189	conflict
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44289.6
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	4
	Total formula weight	581.5
All*	Total formula weight	46044.2

*Water molecules are not included.