PDB: 96046 件ウェブページステータス検索Chemie searchBIRD

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7B3F	Notum S232A in complex with ARUK3003718 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2,3-dihydroindol-1-yl)-4-oxidanylidene-butanoic acid, ... 著者 Zhao, Y, Jone, E.Y. 登録日 2020-11-30 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Structural Insights into Notum Covalent Inhibition. J.Med.Chem., 64, 2021
7B37	Notum complex with ARUK3003718 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2,3-dihydroindol-1-yl)-4-oxidanylidene-butanoic acid, ... 著者 Zhao, Y, Jone, E.Y. 登録日 2020-11-28 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Structural Insights into Notum Covalent Inhibition. J.Med.Chem., 64, 2021
7B2Y	Notum complex with ARUK3003910 分子名称: 1,2-ETHANEDIOL, 2,2-bis(fluoranyl)ethyl 4-(2,3-dihydroindol-1-yl)-4-oxidanylidene-butanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jone, E.Y. 登録日 2020-11-28 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Structural Insights into Notum Covalent Inhibition. J.Med.Chem., 64, 2021
7B2V	Notum complex with ARUK3003906 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jone, E.Y. 登録日 2020-11-28 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Structural Insights into Notum Covalent Inhibition. J.Med.Chem., 64, 2021
3J89	Structural Plasticity of Helical Nanotubes Based on Coiled-Coil Assemblies 分子名称: synthetic peptide 著者 Egelman, E.H, Xu, C, DiMaio, F, Magnotti, E, Modlin, C, Yu, X, Wright, E, Baker, D, Conticello, V.P. 登録日 2014-10-07 公開日 2015-02-11 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural plasticity of helical nanotubes based on coiled-coil assemblies. Structure, 23, 2015
1AEV	INTRODUCTION OF NOVEL SUBSTRATE OXIDATION INTO CYTOCHROME C PEROXIDASE BY CAVITY COMPLEMENTATION: OXIDATION OF 2-AMINOTHIAZOLE AND COVALENT MODIFICATION OF THE ENZYME (2-AMINOTHIAZOLE) 分子名称: 2-AMINOTHIAZOLE, CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE 著者 Musah, R.A, Fitzgerald, M.M, Jensen, G.M, Mcree, D.E, Goodin, D.B. 登録日 1997-02-25 公開日 1997-09-04 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Introduction of novel substrate oxidation into cytochrome c peroxidase by cavity complementation: oxidation of 2-aminothiazole and covalent modification of the enzyme. Biochemistry, 36, 1997
2RR0	Structure of epidermal growth factor-like repeat 12 of mouse Notch-1 receptor 分子名称: Neurogenic locus notch homolog protein 1 著者 Hosoguchi, K, Shimizu, K, Fujitani, N, Nishimura, S. 登録日 2010-02-26 公開日 2010-10-13 最終更新日 2024-10-16 実験手法 SOLUTION NMR 主引用文献 Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor J.Am.Chem.Soc., 132, 2010
2RQZ	Structure of sugar modified epidermal growth factor-like repeat 12 of mouse Notch-1 receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, Neurogenic locus notch homolog protein 1 著者 Shimizu, K, Fujitani, N, Hosoguchi, K, Nishimura, S. 登録日 2010-02-26 公開日 2010-10-13 最終更新日 2020-07-29 実験手法 SOLUTION NMR 主引用文献 Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor J.Am.Chem.Soc., 132, 2010
1AE7	NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2 分子名称: PHOSPHOLIPASE A2, SULFATE ION 著者 Westerlund, B, Nordlund, P, Uhlin, U, Eaker, D, Eklund, H. 登録日 1997-03-06 公開日 1997-05-15 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution. FEBS Lett., 301, 1992
6ZUV	Notum fragment 286 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Zhao, Y, Jones, E.Y. 登録日 2020-07-23 公開日 2020-11-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. J.Med.Chem., 63, 2020
5KZO	Notch1 transmembrane and associated juxtamembrane segment 分子名称: Neurogenic locus notch homolog protein 1 著者 Deatherage, C.L, Lu, Z, Kroncke, B. 登録日 2016-07-25 公開日 2017-05-10 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. Sci Adv, 3, 2017
5CZX	Crystal structure of Notch3 NRR in complex with 20358 Fab 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... 著者 Hu, T, Fryer, C, Chopra, R, Clark, K. 登録日 2015-08-01 公開日 2016-06-01 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
4ZLP	Crystal Structure of Notch3 Negative Regulatory Region 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... 著者 Xu, X, Blacklow, S.C. 登録日 2015-05-01 公開日 2015-08-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.479 Å) 主引用文献 Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
5CZV	Crystal structure of Notch3 NRR in complex with 20350 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... 著者 Hu, T, Fryer, C, Chopra, R, Clark, K. 登録日 2015-08-01 公開日 2016-06-01 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
6TR6	N-acetylserotonin-Notum complex 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jones, E.Y. 登録日 2019-12-17 公開日 2020-01-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum. J. Pineal Res., 68, 2020
8BT7	Notum Inhibitor ARUK3004903 分子名称: 1,2-ETHANEDIOL, 1-[3,4-bis(chloranyl)-5-methyl-indol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-28 公開日 2022-12-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BSQ	Notum Inhibitor ARUK3006561 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-26 公開日 2022-12-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BT5	Notum Inhibitor ARUK3004877 分子名称: 1,2-ETHANEDIOL, 1-(4-fluoranylspiro[2~{H}-indole-3,1'-cyclobutane]-1-yl)ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-27 公開日 2022-12-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BSP	Notum Inhibitor ARUK3006560 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-26 公開日 2022-12-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BTC	Notum Inhibitor ARUK3004558 分子名称: 1,2-ETHANEDIOL, 1-[4,5-bis(chloranyl)-2,3-dihydroindol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-28 公開日 2022-12-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BTI	Notum Inhibitor ARUK3004556 分子名称: 1,2-ETHANEDIOL, 1-(4-chloranylindol-1-yl)-2-methoxy-ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-28 公開日 2022-12-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BSR	Notum Inhibitor ARUK3006562 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-26 公開日 2022-12-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BT2	Notum Inhibitor ARUK3004876 分子名称: 1,2-ETHANEDIOL, 1-[5-chloranyl-4-(trifluoromethyl)-2,3-dihydroindol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-27 公開日 2022-12-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BTE	Notum Inhibitor ARUK3004470 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-28 公開日 2022-12-14 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023
8BT0	Notum Inhibitor ARUK3005518 分子名称: (3~{a}~{S})-2,2-bis(fluoranyl)-3~{a},4-dihydro-3~{H}-pyrrolo[1,2-a]indol-1-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhao, Y, Jones, E.Y, Fish, P. 登録日 2022-11-27 公開日 2022-12-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251, 2023

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