6ZUV

Notum fragment 286

Summary for 6ZUV

• Entry DOI: 10.2210/pdb6zuv/pdb
• Descriptor: Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (6 entities in total)
• Functional Keywords: wnt notum inhibitor complex, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 44760.57

Authors

Zhao, Y.,Jones, E.Y. (deposition date: 2020-07-23, release date: 2020-11-11, Last modification date: 2024-01-31)

• Primary citation: Mahy, W.,Willis, N.J.,Zhao, Y.,Woodward, H.L.,Svensson, F.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Hillier, J.,Kjaer, S.,Frew, S.,Monaghan, A.,Bictash, M.,Salinas, P.C.,Whiting, P.,Vincent, J.P.,Jones, E.Y.,Fish, P.V.; 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.; J.Med.Chem., 63:12942-12956, 2020; PubMed: 33124429; DOI: 10.1021/acs.jmedchem.0c01391

Experimental method

X-RAY DIFFRACTION (1.54 Å)