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4CJM
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Crystal structure of human FGF18
分子名称: FIBROBLAST GROWTH FACTOR 18, SULFATE ION
著者Brown, A, Adam, L.E, Blundell, T.L.
登録日2013-12-21
公開日2014-04-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Crystal Structure of Fibroblast Growth Factor 18 (Fgf18)
Protein Cell, 5, 2014
4OEG
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Crystal Structure Analysis of FGF2-Disaccharide (S9I2) complex
分子名称: 2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
著者Li, Y.C, Hsiao, C.D.
登録日2014-01-13
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4OEE
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Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex
分子名称: 2-deoxy-3-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
著者Li, Y.C, Hsiao, C.D.
登録日2014-01-13
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4OEF
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Crystal Structure Analysis of FGF2-Disaccharide (S6I2) complex
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-1-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid, Fibroblast growth factor 2
著者Li, Y.C, Hsiao, C.D.
登録日2014-01-13
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2.
Acs Chem.Biol., 9, 2014
4Q91
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Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
分子名称: FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
著者Xia, X, Blaber, M.
登録日2014-04-28
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.799 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9G
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Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor
分子名称: FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
著者Blaber, M, Xia, X.
登録日2014-05-01
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.554 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
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Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
分子名称: Fibroblast growth factor 1
著者Blaber, M, Xia, X.
登録日2014-05-01
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QAL
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Crystal structure of C117A mutant of human acidic fibroblast growth factor
分子名称: CITRATE ANION, Fibroblast growth factor 1
著者Blaber, M, Xia, X.
登録日2014-05-05
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
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Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer
分子名称: FORMIC ACID, Fibroblast growth factor 1, SULFATE ION
著者Blaber, M, Xia, X.
登録日2014-05-07
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.519 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
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Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer
分子名称: CITRATE ANION, Fibroblast growth factor 1
著者Blaber, M, Xia, X.
登録日2014-05-08
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.497 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
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Crystal structure of C117S mutant of human acidic fibroblast growth factor
分子名称: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE, ...
著者Blaber, M, Xia, X.
登録日2014-05-09
公開日2015-03-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.491 Å)
主引用文献Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QO3
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Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
分子名称: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE
著者Blaber, M, Xia, X.
登録日2014-06-19
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.047 Å)
主引用文献Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins
To be Published
4XKI
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Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R
分子名称: Fibroblast growth factor 1, GLYCEROL, NONAETHYLENE GLYCOL, ...
著者Xia, X.
登録日2015-01-12
公開日2016-01-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Biophysical characterizations of Fibroblast Growth Factor - 1 mutant with increased heparin binding affinity
To Be Published
4YOL
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Human fibroblast growth factor-1 C16S/A66C/C117A/P134A
分子名称: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE
著者Xia, X, Blaber, M.
登録日2015-03-11
公開日2016-03-16
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105, 2016
5X1O
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PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
分子名称: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Fibroblast growth factor 2
著者Tsao, Y.H.
登録日2017-01-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
To Be Published
5W21
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Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ...
著者Mohammadi, M.
登録日2017-06-05
公開日2018-01-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Nature, 553, 2018
5W59
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Crystal structure of a monomeric human FGF9 in complex with the ectodomain of human FGFR1c
分子名称: Fibroblast growth factor 9, Fibroblast growth factor receptor 1, SULFATE ION
著者Mohammadi, M, Ma, J, Liu, Y.
登録日2017-06-14
公開日2017-08-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.498 Å)
主引用文献Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.
Structure, 25, 2017
6KTR
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Crystal structure of fibroblast growth factor 19 in complex with Fab
分子名称: Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ...
著者Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J.
登録日2019-08-28
公開日2020-07-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.59775758 Å)
主引用文献Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.
Cancer Sci., 111, 2020
6L4O
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Crystal structure of API5-FGF2 complex
分子名称: Apoptosis inhibitor 5, Fibroblast growth factor 2
著者Lee, B.I, Bong, S.M.
登録日2019-10-18
公開日2020-04-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Regulation of mRNA export through API5 and nuclear FGF2 interaction.
Nucleic Acids Res., 48, 2020
6M6F
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BU of 6m6f by Molmil
Solution structure of disulfide bond mutaion of the core domain of Fibroblast growth factor 21 (FGF21)
分子名称: Fibroblast growth factor 21
著者Zhu, L, Zhao, H, Wang, J.
登録日2020-03-14
公開日2021-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
6M6E
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BU of 6m6e by Molmil
Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)
分子名称: Fibroblast growth factor 21
著者Zhu, L, Zhao, H, Wang, J.
登録日2020-03-14
公開日2021-01-20
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Dynamic folding modulation generates FGF21 variant against diabetes.
Embo Rep., 22, 2021
7YSH
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BU of 7ysh by Molmil
Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ...
著者Mohammadi, M, Chen, L.
登録日2022-08-12
公開日2023-04-19
最終更新日2023-07-05
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献Structural basis for FGF hormone signalling.
Nature, 618, 2023
7YSW
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Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ...
著者Mohammadi, M, Chen, L.
登録日2022-08-13
公開日2023-06-14
最終更新日2023-07-05
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Structural basis for FGF hormone signalling.
Nature, 618, 2023
7YSU
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Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ...
著者Mohammadi, M, Chen, L.
登録日2022-08-13
公開日2023-04-19
最終更新日2023-07-05
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis for FGF hormone signalling.
Nature, 618, 2023
8OM6
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Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2
分子名称: Fibroblast growth factor 2
著者Marek, M, Chaloupkova, R, de La Bourdonnaye, G.
登録日2023-03-31
公開日2024-03-06
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2
To Be Published

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