4YOL

Human fibroblast growth factor-1 C16S/A66C/C117A/P134A

Summary for 4YOL

Related2AFG 1JQZ 1RG8 4Q9G 4QAL 3HOM 3FJK
DescriptorFibroblast growth factor 1, CITRATE ANION, IMIDAZOLE, ... (4 entities in total)
Functional Keywordsfibroblast growth factor-1, cysteine-free mutant, fgf-1, intramolecular disulfide, protein binding
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight33998.97
Authors
Xia, X.,Blaber, M. (deposition date: 2015-03-11, release date: 2016-03-16, Last modification date: 2019-02-13)
Primary citation
Xia, X.,Kumru, O.S.,Blaber, S.I.,Middaugh, C.R.,Li, L.,Ornitz, D.M.,Sutherland, M.A.,Tenorio, C.A.,Blaber, M.
Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105:1444-1453, 2016
PubMed: 27019961 (PDB entries with the same primary citation)
DOI: 10.1016/j.xphs.2016.02.010
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.97 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20150 0.8% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 4yol
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Molmil generated image of 4yol
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More Biological unit images

Molmil generated image of 4yol
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Molmil generated image of 4yol
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Molmil generated image of 4yol
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4yol.pdb1.gz [29 KB])
Coordinate files for Biological unit (4yol.pdb2.gz [28.86 KB])