4YOL

Human fibroblast growth factor-1 C16S/A66C/C117A/P134A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor 1	polymer	147	16775.8	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (Human)	FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1
2	C, E (A, B)	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
3	D (A)	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
4	F, G (A, B)	water	water		18.0	321	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
Met -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Ser 16	Cys 31	engineered mutation
Cys 66	Ala 81	engineered mutation
Ala 117	Cys 132	engineered mutation
Ala 134	Pro 149	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33551.7
Non-Polymers*	Number of molecules	3
	Total formula weight	447.3
All*	Total formula weight	33999.0

*Water molecules are not included.